CYP2C8

Gene Symbol	CYP2C8
Entrez Gene	1558
Alt Symbol	CPC8, CYPIIC8, MP-12/MP-20
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 2, subfamily C, polypeptide 8
Other Description	P450 form 1|cytochrome P450 2C8|cytochrome P450 IIC2|cytochrome P450 MP-12|cytochrome P450 MP-20|cytochrome P450 form 1|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8|flavoprotein-linked monooxygenase|microsomal monooxygenase|s-mephenytoin 4-hydroxylase|xenobiotic monooxygenase
Swissprots	P10632 B0AZN2 Q9UCZ9 Q8WWB1 A8K9N8 Q5VX93 B7Z1F6
Accessions	AAR89907 CAA38578 EAW50016 EAW50017 EAW50018 P10632 AK292753 BAF85442 AK293327 BAH11491 AK293328 BAH11492 AK298401 BAH12777 AK303813 BAH14057 AK315823 BAF98714 BC020596 AAH20596 CD014119 DQ891400 ABM82326 DQ894579 ABM85505 M17397 AAA35739 M17398 AAA35740 M21941 AAA52160 M21942 AAA52161 X51535 CAA35915 Y00498 CAA68550 XR_945610 NM_000770 NP_000761 NM_001198853 NP_001185782 NM_001198854 NP_001185783 NM_001198855 NP_001185784 NM_030878
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). {ECO:0000269|PubMed:7574697}.
Subcellular Location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Top Pathways	Chemical carcinogenesis, Arachidonic acid metabolism, Linoleic acid metabolism, Retinol metabolism, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CYP2C8 293T Cell Transient Overexpression Lysate(Denatured) - H00001558-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CYP2C8 overexpression lysate - LY400261 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CYP2C8 293 Cell Lysate - 400308 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Cytochrome P450 2C8 Overexpression Lysate (Native) - NBL1-09685 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CYP2C8 Over-expression Lysate Product - GWB-514E09 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Cytochrome P450 2C8 Overexpression Lysate (Denatured) - H00001558-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human CYP2C8 Knockdown Stable Cell Line - CSC-DC003958 from Creative biogene Category Cell Line Species Human

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