| Gene Symbol |
CYP2C8
|
| Entrez Gene |
1558
|
| Alt Symbol |
CPC8, CYPIIC8, MP-12/MP-20
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 2, subfamily C, polypeptide 8
|
| Other Description |
P450 form 1|cytochrome P450 2C8|cytochrome P450 IIC2|cytochrome P450 MP-12|cytochrome P450 MP-20|cytochrome P450 form 1|cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8|flavoprotein-linked monooxygenase|microsomal monooxygenase|s-mephenytoin 4-hydroxylase|xenobiotic monooxygenase
|
| Swissprots |
P10632 B0AZN2 Q9UCZ9 Q8WWB1 A8K9N8 Q5VX93 B7Z1F6
|
| Accessions |
AAR89907 CAA38578 EAW50016 EAW50017 EAW50018 P10632 AK292753 BAF85442 AK293327 BAH11491 AK293328 BAH11492 AK298401 BAH12777 AK303813 BAH14057 AK315823 BAF98714 BC020596 AAH20596 CD014119 DQ891400 ABM82326 DQ894579 ABM85505 M17397 AAA35739 M17398 AAA35740 M21941 AAA52160 M21942 AAA52161 X51535 CAA35915 Y00498 CAA68550 XR_945610 NM_000770 NP_000761 NM_001198853 NP_001185782 NM_001198854 NP_001185783 NM_001198855 NP_001185784 NM_030878
|
| Function |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). {ECO:0000269|PubMed:7574697}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Top Pathways |
Chemical carcinogenesis, Arachidonic acid metabolism, Linoleic acid metabolism, Retinol metabolism, Drug metabolism - cytochrome P450
|