Gene Symbol | ADSS |
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Entrez Gene | 159 |
Alt Symbol | ADEH, ADSS 2 |
Species | Human |
Gene Type | protein-coding |
Description | adenylosuccinate synthase |
Other Description | AMPSase 2|IMP--aspartate ligase 2|L-type adenylosuccinate synthetase|adSS 2|adenylosuccinate synthetase (Ade(-)H-complementing)|adenylosuccinate synthetase isozyme 2|adenylosuccinate synthetase, acidic isozyme|adenylosuccinate synthetase, liver isozyme |
Swissprots | P30520 B1AQM5 Q96EG7 |
Accessions | CAA47123 EAW77102 EAW77103 P30520 AK025514 AK303886 BAG64822 AK308749 BC012356 AAH12356 BE538442 BG700800 BI559850 EU831433 ACE87120 EU831525 ACE86444 XM_011544108 XP_011542410 XM_011544109 XP_011542411 NM_001126 NP_001117 |
Function | Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. |
Subcellular Location | Cytoplasm. Note=Partially associated with particulate fractions. |
Top Pathways | Purine metabolism, Alanine, aspartate and glutamate metabolism |
AdSS2 CRISPR/Cas9 KO Plasmid (h) - sc-410679 from Santa Cruz Biotechnology
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AdSS2 HDR Plasmid (h) - sc-410679-HDR from Santa Cruz Biotechnology
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AdSS2 Double Nickase Plasmid (h) - sc-410679-NIC from Santa Cruz Biotechnology
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AdSS2 Double Nickase Plasmid (h2) - sc-410679-NIC-2 from Santa Cruz Biotechnology
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AdSS2 CRISPR Activation Plasmid (h) - sc-410679-ACT from Santa Cruz Biotechnology
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AdSS2 CRISPR Activation Plasmid (h2) - sc-410679-ACT-2 from Santa Cruz Biotechnology
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AdSS2 Lentiviral Activation Particles (h) - sc-410679-LAC from Santa Cruz Biotechnology
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AdSS2 Lentiviral Activation Particles (h2) - sc-410679-LAC-2 from Santa Cruz Biotechnology
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AdSS2 siRNA (h) - sc-44960 from Santa Cruz Biotechnology
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AdSS2 shRNA Plasmid (h) - sc-44960-SH from Santa Cruz Biotechnology
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AdSS2 shRNA (h) Lentiviral Particles - sc-44960-V from Santa Cruz Biotechnology
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Adenylosuccinate Synthase RNAi - H00000159-R01 from Novus Biologicals
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MISSION® esiRNA - EHU109091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2906 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2906 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07788 from Sigma-Aldrich
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ADSS siRNA (Human) - CRH0113 from Cohesion Biosciences
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ADSS - MBS8223055 from MyBioSource
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shRNA set against Human ADSS (NM_001126.3) - SHH232826 from Creative biogene
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Human ADSS siRNA - orb260615 from Biorbyt
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ADSS shRNA Plasmid (Human) - CHH0113 from Cohesion Biosciences
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ADSS miRNA 3'UTR clone - MiUTR3H-00076 from Creative biogene
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