| Gene Symbol | CD68 |
|---|---|
| Entrez Gene | 968 |
| Alt Symbol | GP110, LAMP4, SCARD1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD68 molecule |
| Other Description | CD68 antigen|macrophage antigen CD68|macrosialin|scavenger receptor class D, member 1 |
| Swissprots | P34810 Q53XI3 Q53HR6 Q96BI7 B4DVT4 |
| Accessions | AAC70006 EAW90165 P34810 AK222492 BAD96212 AK222514 BAD96234 AK290238 BAF82927 AK298055 BAG60349 AK301223 BAG62796 AW294871 BC015557 AAH15557 BT009923 AAP88925 BX438711 BX647524 DB187273 DQ890631 ABM92248 DQ893801 ABM84727 S57235 AAB25811 NM_001040059 NP_001035148 NM_001251 NP_001242 |
| Function | Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. |
| Subcellular Location | Isoform Short: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. {ECO:0000269|PubMed:18405323}. |
| Top Pathways | Lysosome |