CD68

Gene Symbol	CD68
Entrez Gene	968
Alt Symbol	GP110, LAMP4, SCARD1
Species	Human
Gene Type	protein-coding
Description	CD68 molecule
Other Description	CD68 antigen|macrophage antigen CD68|macrosialin|scavenger receptor class D, member 1
Swissprots	P34810 Q53XI3 Q53HR6 Q96BI7 B4DVT4
Accessions	AAC70006 EAW90165 P34810 AK222492 BAD96212 AK222514 BAD96234 AK290238 BAF82927 AK298055 BAG60349 AK301223 BAG62796 AW294871 BC015557 AAH15557 BT009923 AAP88925 BX438711 BX647524 DB187273 DQ890631 ABM92248 DQ893801 ABM84727 S57235 AAB25811 NM_001040059 NP_001035148 NM_001251 NP_001242
Function	Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
Subcellular Location	Isoform Short: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. {ECO:0000269|PubMed:18405323}.
Top Pathways	Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-CD68-cDNA-Clone - DC04126 from Abgent, a WuXi AppTec company Prices $477.90 Sizes 10 µg Species Human Accession BC015557

CD68 - MBS1275986 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC015557

Human CD68 transcript variant 1 Gene cDNA Clone (full-length ORF Clone) - HG11192-M from Sino Biological Species Human Accession NM_001251.2

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11192-NF from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11192-NM from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11192-CF from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11192-NY from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11192-NH from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11192-CM from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11192-M-F from Sino Biological Species Human

Human CD68 transcript variant 1 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11192-M-N from Sino Biological Species Human Accession NM_001251.2

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11192-CH from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11192-CY from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11192-ACR from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid - HG11192-UT from Sino Biological Species Human

Human CD68 transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11192-ACG from Sino Biological Species Human

Human CD68 ORF clone(NM_001251.2) - CDCL183392 from Creative biogene Species Human

Human CD68 ORF clone (NM_001040059.1) - CDCR044432 from Creative biogene Species Human

Human CD68 ORF Clone (BC015557) - CDCS407005 from Creative biogene Species Human Accession P34810

Human CD68 cDNA Clone(NM_001040059.1) - CDFH003151 from Creative biogene Species Human

Human CD68 cDNA Clone(NM_001251.2) - CDFH003153 from Creative biogene Species Human

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