CD68
| Gene Symbol | CD68 |
|---|---|
| Entrez Gene | 968 |
| Alt Symbol | GP110, LAMP4, SCARD1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CD68 molecule |
| Other Description | CD68 antigen|macrophage antigen CD68|macrosialin|scavenger receptor class D, member 1 |
| Swissprots | P34810 Q53XI3 Q53HR6 Q96BI7 B4DVT4 |
| Accessions | AAC70006 EAW90165 P34810 AK222492 BAD96212 AK222514 BAD96234 AK290238 BAF82927 AK298055 BAG60349 AK301223 BAG62796 AW294871 BC015557 AAH15557 BT009923 AAP88925 BX438711 BX647524 DB187273 DQ890631 ABM92248 DQ893801 ABM84727 S57235 AAB25811 NM_001040059 NP_001035148 NM_001251 NP_001242 |
| Function | Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. |
| Subcellular Location | Isoform Short: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites. {ECO:0000269|PubMed:18405323}. |
| Top Pathways | Lysosome |
CD68 CRISPR/Cas9 KO Plasmid (h) - sc-400211 from Santa Cruz Biotechnology
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CD68 HDR Plasmid (h) - sc-400211-HDR from Santa Cruz Biotechnology
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CD68 Double Nickase Plasmid (h) - sc-400211-NIC from Santa Cruz Biotechnology
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CD68 Double Nickase Plasmid (h2) - sc-400211-NIC-2 from Santa Cruz Biotechnology
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CD68 CRISPR Activation Plasmid (h) - sc-400211-ACT from Santa Cruz Biotechnology
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CD68 CRISPR Activation Plasmid (h2) - sc-400211-ACT-2 from Santa Cruz Biotechnology
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CD68 Lentiviral Activation Particles (h) - sc-400211-LAC from Santa Cruz Biotechnology
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CD68 Lentiviral Activation Particles (h2) - sc-400211-LAC-2 from Santa Cruz Biotechnology
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CD68 siRNA (h) - sc-35019 from Santa Cruz Biotechnology
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CD68 shRNA Plasmid (h) - sc-35019-SH from Santa Cruz Biotechnology
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CD68 shRNA (h) Lentiviral Particles - sc-35019-V from Santa Cruz Biotechnology
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CD68/SR-D1 RNAi - H00000968-R02 from Novus Biologicals
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MISSION® esiRNA - EHU107031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5744 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5744 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04722 from Sigma-Aldrich
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CD68 siRNA (Human) - CRH0689 from Cohesion Biosciences
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CD68/SR-D1 RNAi - H00000968-R01 from Novus Biologicals
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CD68 - MBS8209115 from MyBioSource
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shRNA set against Human CD68 (NM_001251.2) - SHH259281 from Creative biogene
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shRNA set against Human CD68(NM_001251.2) - SHG158523 from Creative biogene
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shRNA set against Human CD68(NM_001040059.1) - SHG158577 from Creative biogene
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shRNA set against Human CD68(NM_001251.2) - SHG158665 from Creative biogene
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CD68 shRNA Plasmid (Human) - CHH0689 from Cohesion Biosciences
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CD68 miRNA 3'UTR clone - MiUTR1H-01899 from Creative biogene
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