| Gene Symbol |
WDR77
|
| Entrez Gene |
79084
|
| Alt Symbol |
HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WD repeat domain 77
|
| Other Description |
WD repeat-containing protein 77|androgen receptor cofactor p44|methylosome protein 50
|
| Swissprots |
B3KMW6 Q96GK4 Q3LID2 Q9BQA1 B4DP38 Q9BWY3 Q6JZZ5 Q53FU2
|
| Accessions |
EAW56493 EAW56494 Q9BQA1 AB073603 BAD38641 AB074171 BAE45736 AF052183 AF478464 AAL79917 AK022860 BAG51128 AK223189 BAD96909 AK296163 BAG58902 AK298179 BAG60450 AY225316 AAP79114 BC001679 AAH01679 BC006477 AAH06477 BC009411 AAH09411 BC011778 AAH11778 BC016946 AAH16946 HQ448191 ADQ32672 NM_024102 NP_077007
|
| Function |
Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.
|
| Tissue Specificity |
Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors. {ECO:0000269|PubMed:12972618, ECO:0000269|PubMed:17437848}.
|