WDR77

Gene Symbol	WDR77
Entrez Gene	79084
Alt Symbol	HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50
Species	Human
Gene Type	protein-coding
Description	WD repeat domain 77
Other Description	WD repeat-containing protein 77|androgen receptor cofactor p44|methylosome protein 50
Swissprots	B3KMW6 Q96GK4 Q3LID2 Q9BQA1 B4DP38 Q9BWY3 Q6JZZ5 Q53FU2
Accessions	EAW56493 EAW56494 Q9BQA1 AB073603 BAD38641 AB074171 BAE45736 AF052183 AF478464 AAL79917 AK022860 BAG51128 AK223189 BAD96909 AK296163 BAG58902 AK298179 BAG60450 AY225316 AAP79114 BC001679 AAH01679 BC006477 AAH06477 BC009411 AAH09411 BC011778 AAH11778 BC016946 AAH16946 HQ448191 ADQ32672 NM_024102 NP_077007
Function	Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}.
Subcellular Location	Nucleus. Cytoplasm. Note=Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.
Tissue Specificity	Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors. {ECO:0000269|PubMed:12972618, ECO:0000269|PubMed:17437848}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WDR77 full length protein - ab132550 from Abcam Category Protein Source Wheat germ Species Human

Human WDR77 peptide - ab66298 from Abcam Category Peptide

WDR77 / MEP50 Antibody Blocking Peptide - LS-E21479 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

WDR77 Recombinant Protein - H00079084-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human WDR77 protein - orb244935 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

WDR77 Blocking Peptide - 33R-6364 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

WDR77 / MEP-50 - H00079084-P01-02 from Acris Antibodies Category Protein Prices $300.00 Sizes 2 µg Source in vitro transl. Species Human

WDR77 fusion protein - ag0147 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Methylosome protein 50(WDR77) - CSB-YP859030HU CSB-BP859030HU CSB-MP859030HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Methylosome protein 50 - CSB-EP859030HU from Cusabio Category Protein Source E.coli Species Human

WDR77 / MEP-50 (full length, N-term HIS tag) - TP760095 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

WDR77 Recombinant Protein Antigen - NBP1-82780PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

WDR77 Recombinant Protein Antigen - NBP1-82779PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

WDR77 Recombinant Protein Antigen - NBP1-82778PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MEP50-Antibody-C-term-Blocking-Peptide - BP6771b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MEP50-Antibody-N-term-Blocking-peptide - BP6771a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WDR77 Peptide, Human - M34GP17455H from Creative Peptides Category Peptide Source Synthetic. Species Human

WDR77 Recombinant Protein (OPCA02448) - OPCA02448 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

Recombinant human Methylosome protein 50 - AP71501 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

MEP50, Recombinant Protein - MBS515709 from MyBioSource Category Protein Prices $325.00, $500.00 Sizes 20 µg, 50 µg Source Sf9 insect cells using baculovirus Species Human

Methylosome protein 50, Recombinant Protein - MBS1420574 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $950.00, $1,170.00, $1,170.00, $1,180.00, $1,400.00, $1,860.00, $1,860.00, $1,860.00, $2,760.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Methylosome protein 50, Recombinant Protein - MBS9421364 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Human

Recombinant Human WDR77 Protein, His-SUMO-tagged - WDR77-1049H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human WDR77 protein, His-tagged - WDR77-12H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human WDR77 protein, GST-tagged - WDR77-318H from Creative Biomart Category Protein Source Insect cell Species Human

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