CHUK
| Gene Symbol | CHUK |
|---|---|
| Entrez Gene | 1147 |
| Alt Symbol | IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 |
| Species | Human |
| Gene Type | protein-coding |
| Description | conserved helix-loop-helix ubiquitous kinase |
| Other Description | I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|TCF-16|inhibitor of nuclear factor kappa-B kinase subunit alpha|transcription factor 16 |
| Swissprots | Q5W0I4 O14666 O15111 Q92467 Q13132 |
| Accessions | AAT49098 EAW49845 O15111 AB209028 BAD92265 AF009225 AAC51671 AF012890 AAC51662 AF080157 AAD08996 AL133012 AL521750 BC034796 BC092514 AAH92514 BM800404 U22512 AAC50713 XM_011539196 XP_011537498 XM_011539197 XP_011537499 XM_011539198 XP_011537500 XR_945589 XR_945590 NM_001278 NP_001269 |
| Function | Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12789342}. Nucleus {ECO:0000269|PubMed:12789342}. Note=Shuttles between the cytoplasm and the nucleus. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | Measles, Toll-like receptor signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Herpes simplex infection, Adipocytokine signaling pathway |
PathScan ® Phospho-IKKα (Ser176/180) Sandwich ELISA Kit - 7073 from Cell Signaling Technology
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PathScan ® Total IKKα Sandwich ELISA Kit - 7078 from Cell Signaling Technology
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Mouse/Human/Rat CHUK / IKKA / IKK Alpha ELISA Kit (Cell-Based ELISA) - LS-F2070 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-CHUK / IKKA / IKK Alpha (Thr23) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1537 from LifeSpan Bioscience
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Rabbit anti-IKK-alpha Antibody, Affinity Purified - PLA0224 from Sigma-Aldrich
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IKKa/b, phosphorylated (Ser176/180) Antibody Sampler Kit, BioAssay - I3000-11B from USBiological Life Science |
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Inhibitor of Nuclear Factor Kappa-B Kinase�� (IKK-ﱫ__ELISA kit, Human, ELISA Kit - CSB-E13794h from ARP American Research Products
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conserved helix-loop-helix ubiquitous kinase, ELISA Kit - MBS701766 from MyBioSource
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IKK-alpha Colorimetric Cell-Based ELISA Kit - CB5357 from Assay Biotechnology
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IKK-alpha/beta Colorimetric Cell-Based ELISA Kit - CB5358 from Assay Biotechnology
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IKK-alpha/beta (Phospho-Ser180/181) Colorimetric Cell-Based ELISA Kit - CBP1126 from Assay Biotechnology
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IKK-alpha (Phospho-Ser176) /IKK-beta (Phospho-Ser177) Colorimetric Cell-Based ELISA Kit - CBP1127 from Assay Biotechnology
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IKK-alpha (Phospho-Thr23) Colorimetric Cell-Based ELISA Kit - CBP1585 from Assay Biotechnology
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Inhibitory Subunit Of NF Kappa B Alpha (IkBa), ELISA Kit - MBS2019498 from MyBioSource
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Inhibitory Subunit Of NF Kappa B Alpha (IkBa), ELISA Kit - MBS2024419 from MyBioSource
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inhibitory subunit of NF-kappaBalpha (IKBalpha), ELISA Kit - MBS9314434 from MyBioSource
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inhibitory subunit of NF-kappaBalpha, IKBalpha - MBS9301556 from MyBioSource
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inhibitory subunit of NF-kappaBalpha, IKBalpha, ELISA Kit - MBS9301447 from MyBioSource
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Human Inhibitor of Nuclear Factor Kappa-B Kinaseα(IKK-α）ELISA kit - CSB-E13794h from Cusabio
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IKK-alpha ELISA Kit - DEIA-XYA1032 from Creative Diagnostics
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IKK-alpha/beta ELISA Kit - DEIA-XYA1035 from Creative Diagnostics
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IKK-alpha (Phospho-Ser176) /IKK-beta (Phospho-Ser177) ELISA Kit - DEIA-XYA1033 from Creative Diagnostics
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IKK-alpha (Phospho-Thr23) ELISA Kit - DEIA-XYA1034 from Creative Diagnostics
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IKK-alpha/beta (Phospho-Ser180/181) ELISA Kit - DEIA-XYA1036 from Creative Diagnostics
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Human CHUK ELISA Kit - E019826 from Biobool
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