CHUK

Gene Symbol	CHUK
Entrez Gene	1147
Alt Symbol	IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Species	Human
Gene Type	protein-coding
Description	conserved helix-loop-helix ubiquitous kinase
Other Description	I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|TCF-16|inhibitor of nuclear factor kappa-B kinase subunit alpha|transcription factor 16
Swissprots	Q5W0I4 O14666 O15111 Q92467 Q13132
Accessions	AAT49098 EAW49845 O15111 AB209028 BAD92265 AF009225 AAC51671 AF012890 AAC51662 AF080157 AAD08996 AL133012 AL521750 BC034796 BC092514 AAH92514 BM800404 U22512 AAC50713 XM_011539196 XP_011537498 XM_011539197 XP_011537499 XM_011539198 XP_011537500 XR_945589 XR_945590 NM_001278 NP_001269
Function	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12789342}. Nucleus {ECO:0000269|PubMed:12789342}. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Specificity	Widely expressed.
Top Pathways	Measles, Toll-like receptor signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Herpes simplex infection, Adipocytokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phospho-IKKα (Ser176)/IKKβ (Ser177) (C84E11) Rabbit mAb - 2078 from Cell Signaling Technology Prices $109.00, $287.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone C84E11

Phospho-IKKα/β (Ser176/180) Antibody II - 2694 from Cell Signaling Technology Prices $109.00, $287.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Phospho-IKKα/β (Ser176/180) (16A6) Rabbit mAb - 2697 from Cell Signaling Technology Prices $109.00, $287.00, $678.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots) Host Rabbit Clonality Monoclonal Clone 16A6

IKKα (3G12) Mouse mAb - 11930 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Mouse Clonality Monoclonal Clone 3G12

IKKα Antibody - 2682 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

Phospho-IKKalpha (Ser176)/IKKbeta(Ser177) Antibody - 2688 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

Phospho-IKKα (Ser180)/IKKβ (Ser181) Antibody - 2681 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

Phospho-IKKα/β (Ser176/180) Antibody - 2687 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

IKKα (B-8) - sc-7606 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IKKα (H-744) - sc-7218 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

IKKα (M-204) - sc-7184 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

IKKα (M-280) - sc-7182 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

IKKα (M-110) - sc-7183 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

IKKα (E-20) - sc-7120 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

IKKα (C-6) - sc-166231 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

IKKα (C-20) - sc-7121 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

IKKα (61AT277) - sc-130153 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

IKKα (4H112) - sc-71332 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

IKKα (14A231) - sc-52932 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

IKKα (0.T.156) - sc-71333 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

p-IKKα (Thr 23) - sc-101706 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-IKK alpha + IKK beta [EPR16628] antibody - ab178870 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR16628

Anti-IKK alpha + IKK beta (phospho S176 + S177) antibody - ab194528 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-IKK alpha + IKK beta (phospho S176 + S177) antibody - ab195931 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IKK alpha + IKK beta (phospho S180 + S181) antibody - ab55341 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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