CHUK

Gene Symbol	CHUK
Entrez Gene	1147
Alt Symbol	IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16
Species	Human
Gene Type	protein-coding
Description	conserved helix-loop-helix ubiquitous kinase
Other Description	I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|TCF-16|inhibitor of nuclear factor kappa-B kinase subunit alpha|transcription factor 16
Swissprots	Q5W0I4 O14666 O15111 Q92467 Q13132
Accessions	AAT49098 EAW49845 O15111 AB209028 BAD92265 AF009225 AAC51671 AF012890 AAC51662 AF080157 AAD08996 AL133012 AL521750 BC034796 BC092514 AAH92514 BM800404 U22512 AAC50713 XM_011539196 XP_011537498 XM_011539197 XP_011537499 XM_011539198 XP_011537500 XR_945589 XR_945590 NM_001278 NP_001269
Function	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12789342}. Nucleus {ECO:0000269|PubMed:12789342}. Note=Shuttles between the cytoplasm and the nucleus.
Tissue Specificity	Widely expressed.
Top Pathways	Measles, Toll-like receptor signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Herpes simplex infection, Adipocytokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IKK alpha full length protein - ab102103 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Human IKK alpha protein fragment - ab158121 from Abcam Category Protein Source Wheat germ Species Human

IKK alpha peptide - ab7892 from Abcam Category Peptide

IKK alpha peptide - ab7893 from Abcam Category Peptide

IKK alpha peptide - ab7894 from Abcam Category Peptide

IKK alpha peptide - ab7610 from Abcam Category Peptide

CHUK / IKKA / IKK Alpha Antibody Blocking Peptide - LS-E3433 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHUK / IKKA / IKK Alpha Antibody Blocking Peptide - LS-E6491 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHUK / IKKA / IKK Alpha Antibody Blocking Peptide - LS-E6773 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHUK / IKKA / IKK Alpha Antibody Blocking Peptide - LS-E29890 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CHUK / IKKA / IKK Alpha Antibody Blocking Peptide - LS-E29891 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CHUK / IKKA / IKK Alpha Antibody Blocking Peptide - LS-E29872 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human IKK alpha Protein - H00001147-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IKK alpha Blocking Peptide - NBP1-76974PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IKK alpha Peptide - NBP1-76936PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

IKK alpha Blocking Peptide - NBP1-76947PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IKK-alphaIKK-beta-Antibody-Center-Blocking-peptide - BP19253c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHUK-AntibodyC-term-Blocking-peptide - BP19658b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IKK alpha peptide - GTX27610 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

IKK alpha peptide - GTX27892 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

IKK alpha peptide - GTX27893 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

IKK alpha peptide - GTX27894 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

IKKA - H00001147-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IKKA - H00001147-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IKKA - P5564 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

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