| Gene Symbol | CHUK |
|---|---|
| Entrez Gene | 1147 |
| Alt Symbol | IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16 |
| Species | Human |
| Gene Type | protein-coding |
| Description | conserved helix-loop-helix ubiquitous kinase |
| Other Description | I-kappa-B kinase 1|I-kappa-B kinase-alpha|IKK-a kinase|IkB kinase alpha subunit|Nuclear factor NFkappaB inhibitor kinase alpha|TCF-16|inhibitor of nuclear factor kappa-B kinase subunit alpha|transcription factor 16 |
| Swissprots | Q5W0I4 O14666 O15111 Q92467 Q13132 |
| Accessions | AAT49098 EAW49845 O15111 AB209028 BAD92265 AF009225 AAC51671 AF012890 AAC51662 AF080157 AAD08996 AL133012 AL521750 BC034796 BC092514 AAH92514 BM800404 U22512 AAC50713 XM_011539196 XP_011537498 XM_011539197 XP_011537499 XM_011539198 XP_011537500 XR_945589 XR_945590 NM_001278 NP_001269 |
| Function | Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Negatively regulates the pathway by phosphorylating the scaffold protein TAXBP1 and thus promoting the assembly of the A20/TNFAIP3 ubiquitin-editing complex (composed of A20/TNFAIP3, TAX1BP1, and the E3 ligases ITCH and RNF11). Therefore, CHUK plays a key role in the negative feedback of NF-kappa-B canonical signaling to |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12789342}. Nucleus {ECO:0000269|PubMed:12789342}. Note=Shuttles between the cytoplasm and the nucleus. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | Measles, Toll-like receptor signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Herpes simplex infection, Adipocytokine signaling pathway |