| Gene Symbol |
ATMIN
|
| Entrez Gene |
23300
|
| Alt Symbol |
ASCIZ, ZNF822
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATM interactor
|
| Other Description |
ATM INteracting protein|ATM/ATR-Substrate Chk2-Interacting Zn++-finger protein|ATM/ATR-substrate CHEK2-interacting zinc finger protein|ATM/ATR-substrate CHK2-interacting zinc finger protein|zinc finger protein 822
|
| Swissprots |
O43313 Q68DC9 A8K4H8
|
| Accessions |
EAW95549 EAW95550 EAW95551 EAW95552 O43313 AB007891 BAA24861 AK025058 AK290943 BAF83632 AK301781 BAH13552 AK302556 BAH13741 BC002701 AAH02701 BI259534 BM693775 BX343387 BX375235 CF593326 CR749457 CAH18291 NM_001300728 NP_001287657 NM_015251 NP_056066
|
| Function |
Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732, ECO:0000269|PubMed:22167198}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732}. Note=Nuclear, in discrete foci during G1 phase.
|
| Tissue Specificity |
Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle. {ECO:0000269|PubMed:15933716}.
|