Gene Symbol | ATMIN |
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Entrez Gene | 23300 |
Alt Symbol | ASCIZ, ZNF822 |
Species | Human |
Gene Type | protein-coding |
Description | ATM interactor |
Other Description | ATM INteracting protein|ATM/ATR-Substrate Chk2-Interacting Zn++-finger protein|ATM/ATR-substrate CHEK2-interacting zinc finger protein|ATM/ATR-substrate CHK2-interacting zinc finger protein|zinc finger protein 822 |
Swissprots | O43313 Q68DC9 A8K4H8 |
Accessions | EAW95549 EAW95550 EAW95551 EAW95552 O43313 AB007891 BAA24861 AK025058 AK290943 BAF83632 AK301781 BAH13552 AK302556 BAH13741 BC002701 AAH02701 BI259534 BM693775 BX343387 BX375235 CF593326 CR749457 CAH18291 NM_001300728 NP_001287657 NM_015251 NP_056066 |
Function | Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM. Binds to the DYNLL1 promoter and activates its transcription. {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732, ECO:0000269|PubMed:22167198}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15933716, ECO:0000269|PubMed:17525732}. Note=Nuclear, in discrete foci during G1 phase. |
Tissue Specificity | Ubiquitously expressed in normal tissues and cancer cell lines with highest levels in placenta and skeletal muscle. {ECO:0000269|PubMed:15933716}. |
ATMIN CRISPR/Cas9 KO Plasmid (h) - sc-411706 from Santa Cruz Biotechnology
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ATMIN HDR Plasmid (h) - sc-411706-HDR from Santa Cruz Biotechnology
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ATMIN Double Nickase Plasmid (h) - sc-411706-NIC from Santa Cruz Biotechnology
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ATMIN Double Nickase Plasmid (h2) - sc-411706-NIC-2 from Santa Cruz Biotechnology
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ATMIN CRISPR Activation Plasmid (h) - sc-411706-ACT from Santa Cruz Biotechnology
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ATMIN CRISPR Activation Plasmid (h2) - sc-411706-ACT-2 from Santa Cruz Biotechnology
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ATMIN Lentiviral Activation Particles (h) - sc-411706-LAC from Santa Cruz Biotechnology
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ATMIN Lentiviral Activation Particles (h2) - sc-411706-LAC-2 from Santa Cruz Biotechnology
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ATMIN siRNA (h) - sc-105098 from Santa Cruz Biotechnology
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ATMIN shRNA Plasmid (h) - sc-105098-SH from Santa Cruz Biotechnology
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ATMIN shRNA (h) Lentiviral Particles - sc-105098-V from Santa Cruz Biotechnology
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ASCIZ RNAi - H00023300-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3663 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3663 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12933 from Sigma-Aldrich
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ATMIN siRNA (Human) - CRH8160 from Cohesion Biosciences
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ATMIN - MBS8237014 from MyBioSource
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shRNA set against Human ASCIZ(NM_015251.2) - SHG080475 from Creative biogene
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Human ATMIN siRNA - orb268662 from Biorbyt
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ATMIN shRNA Plasmid (Human) - CHH8160 from Cohesion Biosciences
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ATMIN miRNA 3'UTR clone - MiUTR1H-00629 from Creative biogene
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