Gene Symbol |
ASB8
|
Entrez Gene |
140461
|
Alt Symbol |
PP14212
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
ankyrin repeat and SOCS box containing 8
|
Other Description |
ASB-8|ankyrin repeat and SOCS box protein 8|ankyrin repeat and SOCS box-containing 8
|
Swissprots |
Q547Q2 A8K1P2 Q9H765
|
Accessions |
EAW57976 Q9H765 AF464877 AAQ04830 AK024908 BAB15033 AK125596 BAC86214 AK289957 BAF82646 AK297013 BAG59546 BC001321 AAH01321 BM837218 BQ009637 CR457336 CAG33617 HQ447366 ADQ31852 XM_005268654 XP_005268711 XM_011537937 XP_011536239 XM_011537938 XP_011536240 NM_024095 NP_077000
|
Function |
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}.
|
Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12559969}.
|
Tissue Specificity |
Highest level of expression in skeletal muscle. Also expressed in heart, brain, placenta, liver, kidney and pancreas. {ECO:0000269|PubMed:12559969}.
|