ECE2
| Gene Symbol | ECE2 |
|---|---|
| Entrez Gene | 9718 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | endothelin converting enzyme 2 |
| Other Description | endothelin-converting enzyme 2 |
| Swissprots | Q96NX3 Q6NTG7 A5PLK8 Q8NFD7 Q6UW36 Q96NX4 Q9BRZ8 O60344 |
| Accessions | EAW78273 EAW78274 EAW78275 EAW78276 EAW78277 EAW78278 EAW78279 O60344 AB011176 BAA25530 AF192531 AAG28399 AF428263 AAL30386 AF428264 AAL30387 AF521189 AAM77664 AK293713 BAH11577 AK293891 BAG57280 AK295270 BAG58256 AK296541 BAG59165 AK309236 AY359003 AAQ89362 BC005835 AAH05835 BC012449 AAH12449 BC069005 AAH69005 BC142950 AAI42951 BC146830 AAI46831 BU568980 HQ448359 ADQ32839 NM_001037324 NP_001032401 NM_001100120 NP_001093590 NM_001100121 NP_001093591 NM_014693 NP_055508 NM_032331 NP_115707 |
| Function | Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. {ECO:0000269|PubMed:12560336}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level). {ECO:0000269|PubMed:17188679}. |
ECE-2 CRISPR/Cas9 KO Plasmid (h) - sc-407055 from Santa Cruz Biotechnology
|
||||||||
ECE-2 HDR Plasmid (h) - sc-407055-HDR from Santa Cruz Biotechnology
|
||||||||
ECE-2 Double Nickase Plasmid (h) - sc-407055-NIC from Santa Cruz Biotechnology
|
||||||||
ECE-2 Double Nickase Plasmid (h2) - sc-407055-NIC-2 from Santa Cruz Biotechnology
|
||||||||
ECE-2 CRISPR Activation Plasmid (h) - sc-407055-ACT from Santa Cruz Biotechnology
|
||||||||
ECE-2 CRISPR Activation Plasmid (h2) - sc-407055-ACT-2 from Santa Cruz Biotechnology
|
||||||||
ECE-2 Lentiviral Activation Particles (h) - sc-407055-LAC from Santa Cruz Biotechnology
|
||||||||
ECE-2 Lentiviral Activation Particles (h2) - sc-407055-LAC-2 from Santa Cruz Biotechnology
|
||||||||
ECE-2 siRNA (h) - sc-72158 from Santa Cruz Biotechnology
|
||||||||
ECE-2 shRNA Plasmid (h) - sc-72158-SH from Santa Cruz Biotechnology
|
||||||||
ECE-2 shRNA (h) Lentiviral Particles - sc-72158-V from Santa Cruz Biotechnology
|
||||||||
ECE-2 RNAi - H00009718-R02 from Novus Biologicals
|
||||||||
ECE-2 RNAi - H00009718-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU099651 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN7628 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7628 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR06331 from Sigma-Aldrich
|
||||||||
ECE2 siRNA (Human) - CRH6486 from Cohesion Biosciences
|
||||||||
ECE2 - MBS8241161 from MyBioSource
|
||||||||
shRNA set against Human ECE2 (NM_001037324.2) - SHH282853 from Creative biogene
|
||||||||
shRNA set against Human ECE2(NM_014693.3) - SHG209257 from Creative biogene
|
||||||||
shRNA set against Human ECE2(NM_001037324.2) - SHG209323 from Creative biogene
|
||||||||
Human ECE2 siRNA - orb266988 from Biorbyt
|
||||||||
ECE2 shRNA Plasmid (Human) - CHH6486 from Cohesion Biosciences
|
||||||||
ECE2 miRNA 3'UTR clone - MiUTR1H-03090 from Creative biogene
|