Gene Symbol | ECE2 |
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Entrez Gene | 9718 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | endothelin converting enzyme 2 |
Other Description | endothelin-converting enzyme 2 |
Swissprots | Q96NX3 Q6NTG7 A5PLK8 Q8NFD7 Q6UW36 Q96NX4 Q9BRZ8 O60344 |
Accessions | EAW78273 EAW78274 EAW78275 EAW78276 EAW78277 EAW78278 EAW78279 O60344 AB011176 BAA25530 AF192531 AAG28399 AF428263 AAL30386 AF428264 AAL30387 AF521189 AAM77664 AK293713 BAH11577 AK293891 BAG57280 AK295270 BAG58256 AK296541 BAG59165 AK309236 AY359003 AAQ89362 BC005835 AAH05835 BC012449 AAH12449 BC069005 AAH69005 BC142950 AAI42951 BC146830 AAI46831 BU568980 HQ448359 ADQ32839 NM_001037324 NP_001032401 NM_001100120 NP_001093590 NM_001100121 NP_001093591 NM_014693 NP_055508 NM_032331 NP_115707 |
Function | Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. {ECO:0000269|PubMed:12560336}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level). {ECO:0000269|PubMed:17188679}. |
ECE-2 (C-17) - sc-27559 from Santa Cruz Biotechnology
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Anti-ECE2 antibody - ab197378 from Abcam
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Anti-ECE2 Antibody - LS-C307344 from LifeSpan Bioscience
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Anti-ECE2 Antibody (aa280-329) - LS-C135166 from LifeSpan Bioscience
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Anti-ECE2 Antibody (aa23-252) - LS-C178952 from LifeSpan Bioscience
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Anti-ECE2 Antibody (aa551-579) - LS-C203974 from LifeSpan Bioscience
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ECE-2 Antibody (233914) [Unconjugated] - MAB16451 from Novus Biologicals
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ECE-2 Antibody [Unconjugated] - AF1645 from Novus Biologicals
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ECE-2 Antibody - NBP1-69061 from Novus Biologicals
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ECE-2 Antibody - NBP1-81495 from Novus Biologicals
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ECE2 Polyclonal Antibody - bs-1753R from Bioss
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Anti-ECE2 antibody produced in mouse - SAB1401488 from Sigma-Aldrich
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Anti-ECE2 antibody produced in rabbit - HPA043346 from Sigma-Aldrich
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ECE2-Antibody-Center - AP20460c from Abgent, a WuXi AppTec company
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ECE2 antibody, Internal - GTX49018 from GeneTex
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Human ECE-2 Antibody - AF1645 from R&D Systems
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Human ECE-2 Affinity Purified Polyclonal Ab, Goat IgG - AF1645-SP from R&D Systems
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Human ECE-2 Antibody - MAB16451 from R&D Systems
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Human ECE-2 MAb (Clone 233914), Rat IgG2A - MAB16451-SP from R&D Systems
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ECE2 Antibody - middle region (OAAB17983) - OAAB17983 from Aviva Systems Biology
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ECE2 antibody - orb13384 from Biorbyt
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ECE2 antibody - 70R-35461 from Fitzgerald
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Anti -ECE2 (Endothelin-converting Enzyme 2, ECE-2, Methyltransferase-like Region,Endothelin-converting Enzyme 2 Region, KIAA0604, UNQ403/PRO740) - 126137 from USBiological Life Science
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ECE2 antibody - orb78248 from Biorbyt
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Ece2 antibody - 70R-8607 from Fitzgerald
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