ECE2

Gene Symbol ECE2
Entrez Gene 9718
Alt Symbol -
Species Human
Gene Type protein-coding
Description endothelin converting enzyme 2
Other Description endothelin-converting enzyme 2
Swissprots Q96NX3 Q6NTG7 A5PLK8 Q8NFD7 Q6UW36 Q96NX4 Q9BRZ8 O60344
Accessions EAW78273 EAW78274 EAW78275 EAW78276 EAW78277 EAW78278 EAW78279 O60344 AB011176 BAA25530 AF192531 AAG28399 AF428263 AAL30386 AF428264 AAL30387 AF521189 AAM77664 AK293713 BAH11577 AK293891 BAG57280 AK295270 BAG58256 AK296541 BAG59165 AK309236 AY359003 AAQ89362 BC005835 AAH05835 BC012449 AAH12449 BC069005 AAH69005 BC142950 AAI42951 BC146830 AAI46831 BU568980 HQ448359 ADQ32839 NM_001037324 NP_001032401 NM_001100120 NP_001093590 NM_001100121 NP_001093591 NM_014693 NP_055508 NM_032331 NP_115707
Function Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. {ECO:0000269|PubMed:12560336}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level). {ECO:0000269|PubMed:17188679}.

ECE-2 (C-17) - sc-27559 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ECE2 antibody - ab197378 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human gastric cancer tissue, labeling ECE2 with ab197378 at a 1/40 dilution. 

Anti-ECE2 Antibody - LS-C307344 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ECE2 Antibody (aa280-329) - LS-C135166 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ECE2 antibody LS-C135166 Western blot of Rat Brain lysate.

Anti-ECE2 Antibody (aa23-252) - LS-C178952 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ECE2 Antibody (aa551-579) - LS-C203974 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ECE2 Antibody western blot of U251 cell line lysates (35 ug/lane). The ECE2 antibody detected the ECE2 protein (arrow).

ECE-2 Antibody (233914) [Unconjugated] - MAB16451 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 233914
ECE‑2 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using 3 µg/mL Rat Anti-Human ECE‑2 Monoclonal Antibody (Catalog # MAB16451) overnight at4 °C. Tissue was stained with the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

ECE-2 Antibody [Unconjugated] - AF1645 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

ECE-2 Antibody - NBP1-69061 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

ECE-2 Antibody - NBP1-81495 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ECE-2 Antibody [NBP1-81495] - Staining of human adrenal gland shows strong cytoplasmic positivity in glandular cells.

ECE2 Polyclonal Antibody - bs-1753R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Mouse brain lysates probed with Rabbit Anti-ECE2 Polyclonal Antibody, Unconjugated (bs-1753R) at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37˚C.

Anti-ECE2 antibody produced in mouse - SAB1401488 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-ECE2, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1401488</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~28.05 kDa using ECE2 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-ECE2 antibody produced in rabbit - HPA043346 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-ECE2: <B>Cat. No. HPA043346</B>: Immunohistochemical staining of human cerebral cortex shows strong nuclear and cytoplasmic positivity in glial cells.

ECE2-Antibody-Center - AP20460c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded H. prostate section using ECE2 Antibody (Center)(Cat#AP20460C). AP20460C was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

ECE2 antibody, Internal - GTX49018 from GeneTex

Prices $299.00
Sizes 50 μg
Anti-ECE2 antibody used in Western blot. GTX49018

Human ECE-2 Antibody - AF1645 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat

Human ECE-2 Affinity Purified Polyclonal Ab, Goat IgG - AF1645-SP from R&D Systems

Host Goat
Clonality Polyclonal

Human ECE-2 Antibody - MAB16451 from R&D Systems

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clone 233914
ECE‑2 in Human Brain. ECE-2 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using 3 µg/mL Rat Anti-Human ECE-2 Monoclonal Antibody (Catalog # MAB16451) overnight at 4 °C. Tissue was stained with the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017 ) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections .

Human ECE-2 MAb (Clone 233914), Rat IgG2A - MAB16451-SP from R&D Systems

Host Rat
Clonality Monoclonal
Clone 233914
ECE‑2 in Human Brain.ECE‑2 was detected in immersion fixed paraffin-embedded sections of human brain (cortex) using 3 µg/mL Rat Anti-Human ECE‑2 Monoclonal Antibody (Catalog # MAB16451) overnight at4 °C. Tissue was stained with the Anti-Rat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS017) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

ECE2 Antibody - middle region (OAAB17983) - OAAB17983 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

ECE2 antibody - orb13384 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of mouse brain lysates using ECE2 antibody

ECE2 antibody - 70R-35461 from Fitzgerald

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

ECE2 antibody - orb78248 from Biorbyt

Prices $425.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin embedded fetal brain showing cytoplasmic staining using ECE2 antibody

Ece2 antibody - 70R-8607 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
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