SMC2

Gene Symbol SMC2
Entrez Gene 10592
Alt Symbol CAP-E, CAPE, SMC-2, SMC2L1
Species Human
Gene Type protein-coding
Description structural maintenance of chromosomes 2
Other Description SMC protein 2|SMC2 (structural maintenance of chromosomes 2, yeast)-like 1|XCAP-E homolog|chromosome-associated protein E|structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E|structural maintenance of chromosomes protein 2
Swissprots O95347 Q9P1P2 Q6IEE0
Accessions EAW58973 EAW58974 EAW58975 EAW58976 EAW58977 O95347 AF092563 AAC72360 AF113673 AAF29579 AJ420415 AJ420453 AK000955 BAG50839 AK001485 BAG50923 AK124957 AK292599 BAF85288 AK307752 AL833191 CAI46187 AY739716 AAW65985 BC003396 AAH03396 BC017845 AAH17845 BC032705 AAH32705 BC055081 AAH55081 BC061906 AAH61906 BC071750 AAH71750 BC107891 AAI07892 BC130385 AAI30386 BC144163 AAI44164 BF969462 BN000163 CAD89875 U46075 AAA86843 XM_006716933 XP_006716996 XM_011518148 XP_011516450 XM_011518149 XP_011516451 XM_011518150 XP_011516452 XM_011518151 XP_011516453 XM_011518152 XP_011516454 XM_011518153 XP_011516455 XM_011518154 XP_011516456 NM_001042550 NP_001036015 NM_001042551 NP_001036016 NM_001265602 NP_001252531 NM_006444 NP_006435
Function Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

SMC2 CRISPR/Cas9 KO Plasmid (h) - sc-411488 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC2 HDR Plasmid (h) - sc-411488-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC2 Double Nickase Plasmid (h) - sc-411488-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC2 Double Nickase Plasmid (h2) - sc-411488-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC2 CRISPR Activation Plasmid (h) - sc-411488-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC2 CRISPR Activation Plasmid (h2) - sc-411488-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC2 Lentiviral Activation Particles (h) - sc-411488-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC2 Lentiviral Activation Particles (h2) - sc-411488-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMC2 siRNA (h) - sc-38389 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMC2 shRNA Plasmid (h) - sc-38389-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMC2 shRNA (h) Lentiviral Particles - sc-38389-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU146451 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19775 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19775 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SMC2 siRNA (Human) - CRH7210 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMC2 RNAi - H00010592-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SMC2 - MBS8211611 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMC2 (NM_006444.2) - SHH413252 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SMC2(NM_001042550.1) - SHL018540 from Creative biogene

Category siRNA
Species Reactivities Human

Human SMC2 siRNA - orb267712 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMC2 shRNA Plasmid (Human) - CHH7210 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMC2 miRNA 3'UTR clone - MiUTR1H-09653 from Creative biogene

Species Reactivities Human
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