SMC2
| Gene Symbol | SMC2 |
|---|---|
| Entrez Gene | 10592 |
| Alt Symbol | CAP-E, CAPE, SMC-2, SMC2L1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | structural maintenance of chromosomes 2 |
| Other Description | SMC protein 2|SMC2 (structural maintenance of chromosomes 2, yeast)-like 1|XCAP-E homolog|chromosome-associated protein E|structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E|structural maintenance of chromosomes protein 2 |
| Swissprots | O95347 Q9P1P2 Q6IEE0 |
| Accessions | EAW58973 EAW58974 EAW58975 EAW58976 EAW58977 O95347 AF092563 AAC72360 AF113673 AAF29579 AJ420415 AJ420453 AK000955 BAG50839 AK001485 BAG50923 AK124957 AK292599 BAF85288 AK307752 AL833191 CAI46187 AY739716 AAW65985 BC003396 AAH03396 BC017845 AAH17845 BC032705 AAH32705 BC055081 AAH55081 BC061906 AAH61906 BC071750 AAH71750 BC107891 AAI07892 BC130385 AAI30386 BC144163 AAI44164 BF969462 BN000163 CAD89875 U46075 AAA86843 XM_006716933 XP_006716996 XM_011518148 XP_011516450 XM_011518149 XP_011516451 XM_011518150 XP_011516452 XM_011518151 XP_011516453 XM_011518152 XP_011516454 XM_011518153 XP_011516455 XM_011518154 XP_011516456 NM_001042550 NP_001036015 NM_001042551 NP_001036016 NM_001265602 NP_001252531 NM_006444 NP_006435 |
| Function | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase. |
Rabbit anti-SMC2 Antibody, Affinity Purified - PLA0018 from Sigma-Aldrich
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7205900 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7219737 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7216993 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7231077 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7231857 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7235190 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7229860 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7214557 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7249382 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7249894 from MyBioSource
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Structural maintenance of chromosomes protein 2 (SMC2), ELISA Kit - MBS7213290 from MyBioSource
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