SMC2

Gene Symbol SMC2
Entrez Gene 10592
Alt Symbol CAP-E, CAPE, SMC-2, SMC2L1
Species Human
Gene Type protein-coding
Description structural maintenance of chromosomes 2
Other Description SMC protein 2|SMC2 (structural maintenance of chromosomes 2, yeast)-like 1|XCAP-E homolog|chromosome-associated protein E|structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E|structural maintenance of chromosomes protein 2
Swissprots O95347 Q9P1P2 Q6IEE0
Accessions EAW58973 EAW58974 EAW58975 EAW58976 EAW58977 O95347 AF092563 AAC72360 AF113673 AAF29579 AJ420415 AJ420453 AK000955 BAG50839 AK001485 BAG50923 AK124957 AK292599 BAF85288 AK307752 AL833191 CAI46187 AY739716 AAW65985 BC003396 AAH03396 BC017845 AAH17845 BC032705 AAH32705 BC055081 AAH55081 BC061906 AAH61906 BC071750 AAH71750 BC107891 AAI07892 BC130385 AAI30386 BC144163 AAI44164 BF969462 BN000163 CAD89875 U46075 AAA86843 XM_006716933 XP_006716996 XM_011518148 XP_011516450 XM_011518149 XP_011516451 XM_011518150 XP_011516452 XM_011518151 XP_011516453 XM_011518152 XP_011516454 XM_011518153 XP_011516455 XM_011518154 XP_011516456 NM_001042550 NP_001036015 NM_001042551 NP_001036016 NM_001265602 NP_001252531 NM_006444 NP_006435
Function Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
Subcellular Location Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

SMC2 (D91E3) Rabbit mAb - 5394 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D91E3
Western blot analysis of extracts from various cell lines using SMC2 (D91E2) Rabbit mAb.

SMC2 (D23C5) Rabbit mAb - 5329 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D23C5
Western blot analysis of extracts from various cell lines using SMC2 (D23C5) Rabbit mAb.

SMC2 (D11F9) Rabbit mAb - 8720 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D11F9
Western blot analysis of extracts from various cell lines using SMC2 (D11F9) Rabbit mAb.

SMC2 (A-16) - sc-10709 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SMC2 (L-20) - sc-10711 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SMC2 antibody - ab10412 from Abcam

Prices $390.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC2 antibody - ab10399 from Abcam

Prices $398.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC2 antibody - ab10411 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC2 antibody - ab116611 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-SMC2 antibody (ab116611) at 0.2 µg/ml + HeLa cell lysate at 35 µgdeveloped using the ECL technique

Anti-SMC2 antibody - C-terminal - ab71427 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SMC2 antibody - C-terminal (ab71427) at 1/60 dilution + Jurkat cell line lysate at 35 µg

Anti-SMC2 Antibody - LS-C48677 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMC2 Antibody (C-Terminus) - LS-C91818 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC2 Antibody - LS-C91816 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC2 Antibody - LS-C91817 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC2 Antibody (N-Terminus) - LS-C144800 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SMC2 Antibody (aa967-983) - LS-C147970 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SMC2 Antibody (aa786-800) - LS-C147971 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-SMC2 Antibody (N-Terminus) - LS-C153565 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SMC2 Antibody (clone 11C1072) - LS-C184131 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 11C1072

Anti-SMC2 Antibody (clone 11C1073) - LS-C184132 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone 11C1073

Anti-SMC2 Antibody (clone KT74) - LS-C193508 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone KT74

Anti-SMC2 Antibody (aa1185-1197) - LS-C139818 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
SMC2 antibody (0.2 ug/ml) staining of HeLa lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SMC2 Antibody (aa51-100) - LS-C80800 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-SMC2 Antibody (aa396-445) - LS-C111092 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SMC2 antibody LS-C111092 Western blot of Fetal Lung lysate.

Anti-SMC2 Antibody - LS-C26729 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blotting using CAP-E antibody on HeLa cell lysate.
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