ABCA7

Gene Symbol	ABCA7
Entrez Gene	10347
Alt Symbol	ABCA-SSN, ABCX
Species	Human
Gene Type	protein-coding
Description	ATP-binding cassette, sub-family A (ABC1), member 7
Other Description	ATP-binding cassette sub-family A member 7|autoantigen SS-N|macrophage ABC transporter
Swissprots	Q9BZC4 Q8IZY2 Q96S58 Q9UKP8 Q9NR73
Accessions	AAN04657 CCQ43618 EAW69556 EAW69557 EAW69558 EAW69559 EAW69560 EAW69561 EAW69562 EAW69563 EAW69564 Q8IZY2 AB055390 BAB62294 AF140342 AAF06727 AF250238 AAF85794 AF328787 AAK00959 AK097344 BAG53455 AK301108 BAG62707 AK310127 AK310909 AL137481 CAB70762 BC172426 AAI72426 BU675136 CD629701 DC405492 XM_006722616 XP_006722679 XM_006722617 XP_006722680 XM_006722618 XP_006722681 XM_011527628 XP_011525930 XM_011527629 XP_011525931 XM_011527630 XP_011525932 XM_011527631 XP_011525933 XM_011527632 XP_011525934 XM_011527633 XP_011525935 XM_011527634 XP_011525936 XM_011527635 XP_011525937 XM_011527636 XP_011525938 XR_936148 XR_936149 XR_936150 XR_936151 XR_936152 XR_936153 XR_936154 XR_936155 NM_019112 NP_061985 NM_033308
Function	Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415}.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the endoplasmic reticulum.
Tissue Specificity	Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow. {ECO:0000269|PubMed:10873640, ECO:0000269|PubMed:11435699, ECO:0000269|PubMed:14592415}.
Top Pathways	ABC transporters

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

ABCA7 (E-11) - sc-377335 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

ABCA7 (K-15) - sc-34556 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ABCA7 (E-14) - sc-34555 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ABCA7 (P-16) - sc-34559 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ABCA7 (L-14) - sc-34557 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

ABCA7 (H-138) - sc-50524 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-ABCA7 antibody - ab186805 from Abcam Host Rabbit Clonality Polyclonal

Anti-ABCA7 antibody - ab186795 from Abcam Host Rabbit Clonality Polyclonal

Anti-ABCA7 antibody - C-terminal - ab186799 from Abcam Host Rabbit Clonality Polyclonal

Anti-ABCA7 antibody - N-terminal - ab186813 from Abcam Host Rabbit Clonality Polyclonal

Anti-ABCA7 Antibody - LS-C126511 from LifeSpan Bioscience Prices $415.00 Sizes 250 µg Host Rat Clonality Monoclonal

Anti-ABCA7 Antibody (PE) - LS-C92059 from LifeSpan Bioscience Prices $355.00 Sizes 100 tst Host Rat Clonality Monoclonal

Anti-ABCA7 Antibody (clone 7A1-144, Biotin) - LS-C141534 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rat Clonality Monoclonal Clone 7A1-144

Anti-ABCA7 Antibody (clone 7A1-144, DY650) - LS-C141535 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rat Clonality Monoclonal Clone 7A1-144

Anti-ABCA7 Antibody (clone 7A1-144, DY488) - LS-C141536 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rat Clonality Monoclonal Clone 7A1-144

Anti-ABCA7 Antibody (clone 7A1-144, HRP) - LS-C141537 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rat Clonality Monoclonal Clone 7A1-144

Anti-ABCA7 Antibody (clone 7A1-144, DY550) - LS-C141538 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rat Clonality Monoclonal Clone 7A1-144

Anti-ABCA7 Antibody (clone 4A7-144.1, RPE) - LS-C188374 from LifeSpan Bioscience Prices $245.00 Sizes 100 tst Host Rat Clonality Monoclonal Clone 4A7-144.1

Anti-ABCA7 Antibody (clone 4A7-144.1) - LS-C188373 from LifeSpan Bioscience Prices $295.00 Sizes 250 µg Host Rat Clonality Monoclonal Clone 4A7-144.1

Anti-ABCA7 Antibody - LS-C342129 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ABCA7 Antibody IHC-plus™ - LS-B5766 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rat Clonality Monoclonal

Anti-ABCA7 Antibody (aa2096-2146) - LS-C291064 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ABCA7 Antibody (clone 7A1-144) - LS-C2754 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rat Clonality Monoclonal Clone 7A1-144

Anti-ABCA7 Antibody (clone 7A1-144) IHC-plus™ - LS-B222 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rat Clonality Monoclonal Clone 7A1-144

ABCA7 Antibody - NBP2-14250 from Novus Biologicals Prices $129.00, $419.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

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