ABCA7

Gene Symbol ABCA7
Entrez Gene 10347
Alt Symbol ABCA-SSN, ABCX
Species Human
Gene Type protein-coding
Description ATP-binding cassette, sub-family A (ABC1), member 7
Other Description ATP-binding cassette sub-family A member 7|autoantigen SS-N|macrophage ABC transporter
Swissprots Q9BZC4 Q8IZY2 Q96S58 Q9UKP8 Q9NR73
Accessions AAN04657 CCQ43618 EAW69556 EAW69557 EAW69558 EAW69559 EAW69560 EAW69561 EAW69562 EAW69563 EAW69564 Q8IZY2 AB055390 BAB62294 AF140342 AAF06727 AF250238 AAF85794 AF328787 AAK00959 AK097344 BAG53455 AK301108 BAG62707 AK310127 AK310909 AL137481 CAB70762 BC172426 AAI72426 BU675136 CD629701 DC405492 XM_006722616 XP_006722679 XM_006722617 XP_006722680 XM_006722618 XP_006722681 XM_011527628 XP_011525930 XM_011527629 XP_011525931 XM_011527630 XP_011525932 XM_011527631 XP_011525933 XM_011527632 XP_011525934 XM_011527633 XP_011525935 XM_011527634 XP_011525936 XM_011527635 XP_011525937 XM_011527636 XP_011525938 XR_936148 XR_936149 XR_936150 XR_936151 XR_936152 XR_936153 XR_936154 XR_936155 NM_019112 NP_061985 NM_033308
Function Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. {ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. Isoform 2 may localize to the endoplasmic reticulum.
Tissue Specificity Expressed in leukocytes (at protein level). Widely expressed. Highly expressed in myelo-lymphatic tissues including peripheral leukocytes, thymus, spleen and bone marrow. Isoform 2 is more abundant in lymph node, spleen, thymus and trachea than isoform 1 which is more strongly expressed in brain and bone marrow. {ECO:0000269|PubMed:10873640, ECO:0000269|PubMed:11435699, ECO:0000269|PubMed:14592415}.
Top Pathways ABC transporters

ABCA7 CRISPR/Cas9 KO Plasmid (h) - sc-403762 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA7 HDR Plasmid (h) - sc-403762-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA7 Double Nickase Plasmid (h) - sc-403762-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA7 Double Nickase Plasmid (h2) - sc-403762-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA7 CRISPR Activation Plasmid (h) - sc-403762-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA7 CRISPR Activation Plasmid (h2) - sc-403762-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA7 Lentiviral Activation Particles (h) - sc-403762-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA7 Lentiviral Activation Particles (h2) - sc-403762-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ABCA7 siRNA (h) - sc-45431 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ABCA7 shRNA Plasmid (h) - sc-45431-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ABCA7 shRNA (h) Lentiviral Particles - sc-45431-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ABCA7 RNAi - H00010347-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ABCA7 RNAi - H00010347-R03 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU040371 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2624 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2624 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ABCA7 siRNA (Human) - CRH7014 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ABCA7 - MBS8228327 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ABCA7(NM_019112.3) - SHG023095 from Creative biogene

Category siRNA
Species Reactivities Human

Human ABCA7 siRNA - orb267516 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ABCA7 shRNA Plasmid (Human) - CHH7014 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ABCA7 miRNA 3'UTR clone - MiUTR1H-00024 from Creative biogene

Species Reactivities Human
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