| Gene Symbol |
ABCC1
|
| Entrez Gene |
4363
|
| Alt Symbol |
ABC29, ABCC, GS-X, MRP, MRP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
|
| Other Description |
ATP-binding cassette transporter variant ABCC1delta-ex13|ATP-binding cassette transporter variant ABCC1delta-ex13&14|ATP-binding cassette transporter variant ABCC1delta-ex25|ATP-binding cassette transporter variant ABCC1delta-ex25&26|LTC4 transporter|leukotriene C(4) transporter|multidrug resistance-associated protein 1
|
| Swissprots |
Q9UQ97 P78419 O43333 P33527 Q9UQ99 Q59GI9 C9JPJ4 O14819 A3RJX2 Q9UQA0
|
| Accessions |
AAB82786 AAB83979 AAB83980 AAB83981 AAB83982 AAB83983 AAC05808 AAC15784 ABN79590 EAW53936 EAW53937 EAW53938 EAW53939 EAW53940 EAW53941 EAW53942 EAW53943 EAW53944 EAW53945 EAW53946 EAW53947 EAW53948 EAW53949 P33527 AB209120 BAD92357 AJ003198 AK311015 BC001636 AAH01636 BC156353 AAI56354 BC157105 AAI57106 BX648866 CR749835 CAH18691 HQ917064 AEK86268 HQ917065 AEK86269 HQ917066 AEK86270 HQ917067 AEK86271 L05628 AAB46616 X78338 XM_011522497 XP_011520799 XM_011522498 XP_011520800 NM_004996 NP_004987 NM_019862 NM_019898 NM_019899 NM_019900 NM_019901 NM_019902
|
| Function |
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency. {ECO:0000269|PubMed:10064732, ECO:0000269|PubMed:11114332, ECO:0000269|PubMed:16230346}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:16230346}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:16230346}.
|
| Tissue Specificity |
Lung, testis and peripheral blood mononuclear cells.
|
| Top Pathways |
ABC transporters, Vitamin digestion and absorption, MicroRNAs in cancer, Sphingolipid signaling pathway
|