Gene Symbol | SIAH3 |
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Entrez Gene | 283514 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | siah E3 ubiquitin protein ligase family member 3 |
Other Description | seven in absentia homolog 3|siah-3 |
Swissprots | Q8N8M6 B7ZBP0 Q8IW03 |
Accessions | Q8IW03 AK125411 BC041372 AAH41372 BC148396 AAI48397 DA804734 NM_198849 NP_942146 |
Function | Negative regulator of PARK2 translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PARK2 targeting to dysfunctional depolarized mitochondria. {ECO:0000269|PubMed:24270810}. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:24270810}. |
SIAH3 CRISPR/Cas9 KO Plasmid (h) - sc-415321 from Santa Cruz Biotechnology
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SIAH3 HDR Plasmid (h) - sc-415321-HDR from Santa Cruz Biotechnology
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SIAH3 Double Nickase Plasmid (h) - sc-415321-NIC from Santa Cruz Biotechnology
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SIAH3 Double Nickase Plasmid (h2) - sc-415321-NIC-2 from Santa Cruz Biotechnology
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SIAH3 CRISPR Activation Plasmid (h) - sc-415321-ACT from Santa Cruz Biotechnology
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SIAH3 CRISPR Activation Plasmid (h2) - sc-415321-ACT-2 from Santa Cruz Biotechnology
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SIAH3 Lentiviral Activation Particles (h) - sc-415321-LAC from Santa Cruz Biotechnology
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SIAH3 Lentiviral Activation Particles (h2) - sc-415321-LAC-2 from Santa Cruz Biotechnology
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SIAH3 siRNA (h) - sc-75452 from Santa Cruz Biotechnology
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SIAH3 shRNA Plasmid (h) - sc-75452-SH from Santa Cruz Biotechnology
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SIAH3 shRNA (h) Lentiviral Particles - sc-75452-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN19322 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19322 from Sigma-Aldrich
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SIAH3 siRNA (Human) - CRJ6912 from Cohesion Biosciences
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SIAH3 - MBS827377 from MyBioSource
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shRNA set against Human SIAH3 (NM_198849.2) - SHH407368 from Creative biogene
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Human SIAH3 siRNA - orb277413 from Biorbyt
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SIAH3 shRNA Plasmid (Human) - CHJ6912 from Cohesion Biosciences
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SIAH3 miRNA 3'UTR clone - MiUTR1H-05760 from Creative biogene
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