PIKFYVE

Gene Symbol PIKFYVE
Entrez Gene 200576
Alt Symbol CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29
Species Human
Gene Type protein-coding
Description phosphoinositide kinase, FYVE finger containing
Other Description 1-phosphatidylinositol 3-phosphate 5-kinase|1-phosphatidylinositol-3-phosphate 5-kinase|PIPkin-III|epididymis luminal protein 37|phosphatidylinositol 3-phosphate 5-kinase type III|phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III|type III PIP kinase|zinc finger, FYVE domain containing 29
Swissprots Q8N5H0 Q08AR7 Q9Y2I7 Q8NB67 Q53T36 Q53ST3 Q08AR8
Accessions AAX93222 AAY14870 CCQ43864 EAW70444 EAW70445 EAW70446 EAW70447 EAW70448 EAW70449 Q9Y2I7 AB023198 BAA76825 AK091482 BAC03674 AK127769 BAC87123 AL122124 AY457063 AAR19397 BC017736 BC032389 AAH32389 BC035705 BC125052 AAI25053 BC125053 AAI25054 BC156451 AAI56452 BC172527 AAI72527 BG287802 BX640810 EU794609 ACJ13663 HQ447333 ADQ31819 XM_011510778 XP_011509080 XM_011510779 XP_011509081 XM_011510780 XP_011509082 XM_011510781 XP_011509083 XM_011510782 XP_011509084 XM_011510783 XP_011509085 XM_011510784 XP_011509086 XM_011510785 XP_011509087 XM_011510786 XP_011509088 XM_011510787 XP_011509089 XM_011510788 XP_011509090 XM_011510789 XP_011509091 XM_011510790 XP_011509092 XM_011510791 XP_011509093 XM_011510792 XP_011509094 XR_922888 NM_001178000 NP_001171471 NM_015040 NP_055855 NM_152671 NP_689884 NM_001002881
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:17556371}.
Subcellular Location Endosome membrane {ECO:0000269|PubMed:11706043, ECO:0000269|PubMed:17556371}. Note=Mainly associated with membranes of the late endocytic pathway.
Top Pathways Phagosome, Inositol phosphate metabolism, Regulation of actin cytoskeleton, Phosphatidylinositol signaling system

PIP5KIII (H-300) - sc-98631 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

PIP5KIII (C-14) - sc-83845 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PIP5KIII (E-20) - sc-83846 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PIP5KIII (P-20) - sc-83847 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PIP5KIII (64-Q6) - sc-100408 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
PIP5KIII (64-Q6): sc-100408. Western blot analysis of PIP5KIII expression in HeLa whole cell lysate.

Anti-PIP5K3 (phospho S307) antibody - ab62467 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab62467, at 1/50 dilution, staining PIP5K3 in paraffin embedded human brain tissue by Immunohistochemsitry in the absence (left image) or presence (right image) of the immunising peptide.

Anti-PIP5K3 antibody - ab60207 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PIP5K3 antibody (ab60207)Lane 1 : Non-transfected 293 cell lysateLane 2 : Transiently transfected 293 cell lysateLysates/proteins at 2 µg per lane.

Anti-PIP5K3 antibody - ab58126 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
PIP5K3 antibody (ab58126) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human testis.

Anti-PIP5K3 antibody - ab137907 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PIP5K3 antibody (ab137907) at 1/500 dilution + Jurkat cell lysate at 30 µg

Anti-PIP5K3 antibody - ab173448 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-PIP5K3 antibody (ab173448) at 1 µg/mlLane 1 : PIP5K3 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.developed using the ECL technique

Anti-PIP5K3 antibody - C-terminal - ab197792 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human thyroid tissue labeling PIP5K3 using ab197792 at a 1/50 dilution.

Anti-PIKFYVE / PIP5K Antibody (C-Terminus) - LS-C209414 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa1531-1561, AP) - LS-C245354 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa1531-1561, APC) - LS-C245355 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa1531-1561, Biotin) - LS-C245356 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa273-322) - LS-C199442 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using PIP5K Antibody. The sample on the right was incubated with synthetic peptide.

Anti-PIKFYVE / PIP5K Antibody (aa1531-1561, FITC) - LS-C245357 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa1531-1561, PE) - LS-C245360 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa1531-1561, Azide-free, HRP) - LS-C247766 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa1680-1931, Biotin) - LS-C298353 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa1680-1931, FITC) - LS-C301459 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (Internal) - LS-C328250 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PIKFYVE / PIP5K Antibody (aa342-452, Azide-free) - LS-C330586 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PIKFYVE / PIP5K Antibody (phospho-Ser307) - LS-C199443 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain, using PIP5K (Phospho-Ser307) Antibody. The sample on the right was incubated with synthetic peptide.

Anti-PIKFYVE / PIP5K Antibody (aa71-120) - LS-C119339 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of COS7 cells, using PIP5K Antibody. The picture on the right is treated with the synthesized peptide.
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