| Gene Symbol |
PIKFYVE
|
| Entrez Gene |
200576
|
| Alt Symbol |
CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoinositide kinase, FYVE finger containing
|
| Other Description |
1-phosphatidylinositol 3-phosphate 5-kinase|1-phosphatidylinositol-3-phosphate 5-kinase|PIPkin-III|epididymis luminal protein 37|phosphatidylinositol 3-phosphate 5-kinase type III|phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III|type III PIP kinase|zinc finger, FYVE domain containing 29
|
| Swissprots |
Q8N5H0 Q08AR7 Q9Y2I7 Q8NB67 Q53T36 Q53ST3 Q08AR8
|
| Accessions |
AAX93222 AAY14870 CCQ43864 EAW70444 EAW70445 EAW70446 EAW70447 EAW70448 EAW70449 Q9Y2I7 AB023198 BAA76825 AK091482 BAC03674 AK127769 BAC87123 AL122124 AY457063 AAR19397 BC017736 BC032389 AAH32389 BC035705 BC125052 AAI25053 BC125053 AAI25054 BC156451 AAI56452 BC172527 AAI72527 BG287802 BX640810 EU794609 ACJ13663 HQ447333 ADQ31819 XM_011510778 XP_011509080 XM_011510779 XP_011509081 XM_011510780 XP_011509082 XM_011510781 XP_011509083 XM_011510782 XP_011509084 XM_011510783 XP_011509085 XM_011510784 XP_011509086 XM_011510785 XP_011509087 XM_011510786 XP_011509088 XM_011510787 XP_011509089 XM_011510788 XP_011509090 XM_011510789 XP_011509091 XM_011510790 XP_011509092 XM_011510791 XP_011509093 XM_011510792 XP_011509094 XR_922888 NM_001178000 NP_001171471 NM_015040 NP_055855 NM_152671 NP_689884 NM_001002881
|
| Function |
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:17556371}.
|
| Subcellular Location |
Endosome membrane {ECO:0000269|PubMed:11706043, ECO:0000269|PubMed:17556371}. Note=Mainly associated with membranes of the late endocytic pathway.
|
| Top Pathways |
Phagosome, Inositol phosphate metabolism, Regulation of actin cytoskeleton, Phosphatidylinositol signaling system
|