PIKFYVE

Gene Symbol	PIKFYVE
Entrez Gene	200576
Alt Symbol	CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29
Species	Human
Gene Type	protein-coding
Description	phosphoinositide kinase, FYVE finger containing
Other Description	1-phosphatidylinositol 3-phosphate 5-kinase|1-phosphatidylinositol-3-phosphate 5-kinase|PIPkin-III|epididymis luminal protein 37|phosphatidylinositol 3-phosphate 5-kinase type III|phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III|type III PIP kinase|zinc finger, FYVE domain containing 29
Swissprots	Q8N5H0 Q08AR7 Q9Y2I7 Q8NB67 Q53T36 Q53ST3 Q08AR8
Accessions	AAX93222 AAY14870 CCQ43864 EAW70444 EAW70445 EAW70446 EAW70447 EAW70448 EAW70449 Q9Y2I7 AB023198 BAA76825 AK091482 BAC03674 AK127769 BAC87123 AL122124 AY457063 AAR19397 BC017736 BC032389 AAH32389 BC035705 BC125052 AAI25053 BC125053 AAI25054 BC156451 AAI56452 BC172527 AAI72527 BG287802 BX640810 EU794609 ACJ13663 HQ447333 ADQ31819 XM_011510778 XP_011509080 XM_011510779 XP_011509081 XM_011510780 XP_011509082 XM_011510781 XP_011509083 XM_011510782 XP_011509084 XM_011510783 XP_011509085 XM_011510784 XP_011509086 XM_011510785 XP_011509087 XM_011510786 XP_011509088 XM_011510787 XP_011509089 XM_011510788 XP_011509090 XM_011510789 XP_011509091 XM_011510790 XP_011509092 XM_011510791 XP_011509093 XM_011510792 XP_011509094 XR_922888 NM_001178000 NP_001171471 NM_015040 NP_055855 NM_152671 NP_689884 NM_001002881
Function	The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes. {ECO:0000269|PubMed:17556371}.
Subcellular Location	Endosome membrane {ECO:0000269|PubMed:11706043, ECO:0000269|PubMed:17556371}. Note=Mainly associated with membranes of the late endocytic pathway.
Top Pathways	Phagosome, Inositol phosphate metabolism, Regulation of actin cytoskeleton, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PIP5K3 full length protein - ab165864 from Abcam Category Protein Source Wheat germ Species Human

Human PIP5K3 protein fragment - ab165865 from Abcam Category Protein Source Wheat germ Species Human

PIKFYVE / PIP5K Antibody Blocking Peptide - LS-E8739 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PIKFyve/PIP5K3 Protein - H00200576-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PIKFyve/PIP5K3 Peptide - P2334 from Novus Biologicals Category Peptide Species Human

PIP5K3-Antibody-C-term-Blocking-Peptide - BP7172c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIP5K3-Antibody-Center-Blocking-Peptide - BP7172a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PI5K-Antibody-C-term-K2016-Blocking-Peptide - BP8036a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PIP5K3 - H00200576-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PIP5K3 - H00200576-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PIP5K3 - H00200576-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PIP5K3 - H00200576-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PIP5K3 fusion protein - ag4366 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PIP5K3 fusion protein - Ag4177 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PIP5K3 Peptide - 350536 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human PIKFYVE, GST-tagged - PIKFYVE-120H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Phosphoinositide Kinase, FYVE Finger Containing (PIKFYVE) - RPL531Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

PIP5K3 protein-GST fusion - 009-001-S99 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

PIP5K3 protein-GST fusion - 009-001-S99S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human 1-phosphatidylinositol 3-phosphate 5-kinase(PIKFYVE) ,partial - CSB-YP896875HU CSB-EP896875HU CSB-BP896875HU CSB-MP896875HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Anti-PIKFyve - 4082 from R&D Systems Category Peptide Prices $369.00 Sizes 100 µg

1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE), partial, Recombinant Protein - MBS1462118 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PIP5K3 (transcript variant 3) - TP312288 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PIP5K3 (transcript variant 4) - TP330258 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PIP5K3 (full length, N-term HIS tag, transcript variant 4) - TP760677 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

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