Gene Symbol | AMOTL1 |
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Entrez Gene | 154810 |
Alt Symbol | JEAP |
Species | Human |
Gene Type | protein-coding |
Description | angiomotin like 1 |
Other Description | angiomotin-like protein 1|junction-enriched and associated protein |
Swissprots | Q8IY63 Q63HK7 Q8WXD1 Q8TEN8 Q8NDN0 Q96CM5 |
Accessions | EAW66943 EAW66944 EAW66945 Q8IY63 AF453742 AAL49764 AK024350 AK074084 BAB84910 AK093699 BAC04218 AL137281 AL833833 CAD38693 AM393663 CAL38539 BC014126 AAH14126 BC018449 BC037539 AAH37539 BC040683 BX648729 CAH56180 XM_005273798 XP_005273855 XM_005273801 XP_005273858 XM_006718772 XP_006718835 XM_011542626 XP_011540928 XM_011542627 XP_011540929 XM_011542628 XP_011540930 NM_001301007 NP_001287936 NM_130847 NP_570899 |
Function | Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000269|PubMed:22362771}. |
Subcellular Location | Cell junction, tight junction {ECO:0000250}. |
Top Pathways | Tight junction |
Angiomotin-L1 CRISPR/Cas9 KO Plasmid (h) - sc-409052 from Santa Cruz Biotechnology
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Angiomotin-L1 HDR Plasmid (h) - sc-409052-HDR from Santa Cruz Biotechnology
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Angiomotin-L1 Double Nickase Plasmid (h) - sc-409052-NIC from Santa Cruz Biotechnology
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Angiomotin-L1 Double Nickase Plasmid (h2) - sc-409052-NIC-2 from Santa Cruz Biotechnology
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Angiomotin-L1 CRISPR Activation Plasmid (h) - sc-409052-ACT from Santa Cruz Biotechnology
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Angiomotin-L1 CRISPR Activation Plasmid (h2) - sc-409052-ACT-2 from Santa Cruz Biotechnology
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Angiomotin-L1 Lentiviral Activation Particles (h) - sc-409052-LAC from Santa Cruz Biotechnology
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Angiomotin-L1 Lentiviral Activation Particles (h2) - sc-409052-LAC-2 from Santa Cruz Biotechnology
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Angiomotin-L1 siRNA (h) - sc-72491 from Santa Cruz Biotechnology
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Angiomotin-L1 shRNA Plasmid (h) - sc-72491-SH from Santa Cruz Biotechnology
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Angiomotin-L1 shRNA (h) Lentiviral Particles - sc-72491-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU083201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3122 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3122 from Sigma-Aldrich
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AMOTL1 siRNA (Human) - CRJ5804 from Cohesion Biosciences
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AMOTL1 - MBS8239530 from MyBioSource
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shRNA set against Human AMOTL1 (NM_130847.2) - SHH235870 from Creative biogene
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shRNA set against Human AMOTL1(NM_130847.2) - SHG056379 from Creative biogene
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Human AMOTL1 siRNA - orb276305 from Biorbyt
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AMOTL1 shRNA Plasmid (Human) - CHJ5804 from Cohesion Biosciences
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AMOTL1 miRNA 3'UTR clone - MiUTR1H-00341 from Creative biogene
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