| Gene Symbol | RBX1 |
|---|---|
| Entrez Gene | 9978 |
| Alt Symbol | BA554C12.1, RNF75, ROC1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ring-box 1, E3 ubiquitin protein ligase |
| Other Description | E3 ubiquitin-protein ligase RBX1|RING box protein 1|RING finger protein 75|RING-box protein 1|ZYP protein|regulator of cullins 1 |
| Swissprots | Q9D1S2 B2RDY1 Q9Y254 Q8N6Z8 Q9WUK9 P62877 |
| Accessions | CAT16469 CDM22122 EAW60402 EAW60403 P62877 AF085906 AF140598 AAD29715 AF142059 AAD30146 AK090764 AK315722 BAG38078 AY099360 AAM21718 BC001466 AAH01466 BC017370 AAH17370 CR456560 CAG30446 CU013160 CAK54591 CU013448 CAK54890 DA353856 DN602016 NM_014248 NP_055063 |
| Function | E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11027288}. Nucleus {ECO:0000269|PubMed:11027288}. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | Wnt signaling pathway, Nucleotide excision repair, Renal cell carcinoma, Circadian rhythm, Oocyte meiosis |