RBX1

Gene Symbol	RBX1
Entrez Gene	9978
Alt Symbol	BA554C12.1, RNF75, ROC1
Species	Human
Gene Type	protein-coding
Description	ring-box 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RBX1|RING box protein 1|RING finger protein 75|RING-box protein 1|ZYP protein|regulator of cullins 1
Swissprots	Q9D1S2 B2RDY1 Q9Y254 Q8N6Z8 Q9WUK9 P62877
Accessions	CAT16469 CDM22122 EAW60402 EAW60403 P62877 AF085906 AF140598 AAD29715 AF142059 AAD30146 AK090764 AK315722 BAG38078 AY099360 AAM21718 BC001466 AAH01466 BC017370 AAH17370 CR456560 CAG30446 CU013160 CAK54591 CU013448 CAK54890 DA353856 DN602016 NM_014248 NP_055063
Function	E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11027288}. Nucleus {ECO:0000269|PubMed:11027288}.
Tissue Specificity	Widely expressed.
Top Pathways	Wnt signaling pathway, Nucleotide excision repair, Renal cell carcinoma, Circadian rhythm, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ROC1 full length protein - ab157035 from Abcam Category Protein Source E. coli Species Human

Human ROC1 peptide - ab97983 from Abcam Category Peptide

RBX1 / ROC1 Antibody Blocking Peptide - LS-E10601 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RBX1 Protein - H00009978-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RBX1 Blocking Peptide - 33R-6836 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RBX1 / RNF75 - H00009978-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RBX1 / RNF75 - H00009978-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RBX1 fusion protein - Ag7005 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RBX1 fusion protein - ag6685 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human RBX1 - RBX1-31333TH from Creative Biomart Category Protein Source E. coli

Recombinant Human RBX1, His-tagged - RBX1-2227H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Ring-box 1, His-tagged - RBX1-2389H from Creative Biomart Category Protein Source E. coli.

Recombinant Human RBX1, T7-tagged - RBX1-2902H from Creative Biomart Category Protein Source E.Coli.

Recombinant Human E3 ubiquitin-protein ligase RBX1(RBX1) - CSB-YP019496HU CSB-EP019496HU CSB-BP019496HU CSB-MP019496HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RBX1 Protein - abx164994 from Abbexa Category Protein Species Human, Mouse, Rat

RBX1 / RNF75 - TP300348 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RBX1 Recombinant Protein Antigen - NBP1-88742PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RBX1-Blocking-Peptide-C-term - BP20572a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RBX1 Peptide, Human - M34GP13103H from Creative Peptides Category Peptide Source Synthetic. Species Human

RBX1 Recombinant Protein (Human) (OPED00126) - OPED00126 from Aviva Systems Biology Category Protein Prices $300.00 Sizes 25 µg Source E. Coli Species Human

E3 ubiquitin-protein ligase RBX1 (RBX1), Recombinant Protein - MBS967513 from MyBioSource Category Protein Prices $845.00, $845.00, $1,065.00, $1,065.00, $1,190.00, $1,190.00, $1,650.00, $1,650.00, $1,650.00, $2,360.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RBX1 Recombinant Protein (Human) (OPCA04759) - OPCA04759 from Aviva Systems Biology Category Protein Species Human

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