| Gene Symbol |
FDX1
|
| Entrez Gene |
2230
|
| Alt Symbol |
ADX, FDX, LOH11CR1D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ferredoxin 1
|
| Other Description |
adrenal ferredoxin|adrenodoxin, mitochondrial|ferredoxin-1|hepatoredoxin|mitochondrial adrenodoxin
|
| Swissprots |
P10109 Q53YD6 B0YJ14
|
| Accessions |
AAA35855 AAA35856 AAA50462 AAD15277 ACA05992 EAW67132 P10109 AA505582 AB096243 BC010284 AAH10284 BC017063 AAH17063 BQ650029 BT006681 AAP35327 CN333249 DB459133 J03548 AAA96806 M18003 AAA76853 M34788 AAA35829 NM_004109 NP_004100
|
| Function |
Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. {ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}.
|
| Subcellular Location |
Mitochondrion matrix {ECO:0000269|PubMed:20547883}.
|
| Tissue Specificity |
Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level). {ECO:0000269|PubMed:20547883}.
|
![Western Blot: FDX1 Overexpression Lysate (Adult Normal) [NBL1-10670] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FDX1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1153_FDX1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10670-img0002.jpg)