Gene Symbol | FDX1 |
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Entrez Gene | 2230 |
Alt Symbol | ADX, FDX, LOH11CR1D |
Species | Human |
Gene Type | protein-coding |
Description | ferredoxin 1 |
Other Description | adrenal ferredoxin|adrenodoxin, mitochondrial|ferredoxin-1|hepatoredoxin|mitochondrial adrenodoxin |
Swissprots | P10109 Q53YD6 B0YJ14 |
Accessions | AAA35855 AAA35856 AAA50462 AAD15277 ACA05992 EAW67132 P10109 AA505582 AB096243 BC010284 AAH10284 BC017063 AAH17063 BQ650029 BT006681 AAP35327 CN333249 DB459133 J03548 AAA96806 M18003 AAA76853 M34788 AAA35829 NM_004109 NP_004100 |
Function | Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. {ECO:0000269|PubMed:20547883, ECO:0000269|PubMed:21636783}. |
Subcellular Location | Mitochondrion matrix {ECO:0000269|PubMed:20547883}. |
Tissue Specificity | Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level). {ECO:0000269|PubMed:20547883}. |
ADX CRISPR/Cas9 KO Plasmid (h) - sc-410782 from Santa Cruz Biotechnology
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ADX HDR Plasmid (h) - sc-410782-HDR from Santa Cruz Biotechnology
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ADX Double Nickase Plasmid (h) - sc-410782-NIC from Santa Cruz Biotechnology
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ADX Double Nickase Plasmid (h2) - sc-410782-NIC-2 from Santa Cruz Biotechnology
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ADX CRISPR Activation Plasmid (h) - sc-410782-ACT from Santa Cruz Biotechnology
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ADX CRISPR Activation Plasmid (h2) - sc-410782-ACT-2 from Santa Cruz Biotechnology
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ADX Lentiviral Activation Particles (h) - sc-410782-LAC from Santa Cruz Biotechnology
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ADX Lentiviral Activation Particles (h2) - sc-410782-LAC-2 from Santa Cruz Biotechnology
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ADX siRNA (h) - sc-105047 from Santa Cruz Biotechnology
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ADX shRNA Plasmid (h) - sc-105047-SH from Santa Cruz Biotechnology
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ADX shRNA (h) Lentiviral Particles - sc-105047-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU108921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8612 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8612 from Sigma-Aldrich
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FDX1 siRNA (Human) - CRH1556 from Cohesion Biosciences
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FDX1 RNAi - H00002230-R01 from Novus Biologicals
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FDX1 - MBS8232882 from MyBioSource
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shRNA set against Human FDX1 (NM_004109.4) - SHH293941 from Creative biogene
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FDX1 shRNA Plasmid (Human) - CHH1556 from Cohesion Biosciences
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FDX1 miRNA 3'UTR clone - MiUTR4H-TG03512 from Creative biogene
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