| Gene Symbol | ITGA2 |
|---|---|
| Entrez Gene | 3673 |
| Alt Symbol | BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
| Other Description | CD49 antigen-like family member B|VLA2 receptor, alpha-2 subunit|collagen receptor|human platelet alloantigen system 5|integrin alpha-2|platelet antigen Br|platelet glycoprotein GPIa|platelet membrane glycoprotein Ia|very late activation protein 2 receptor, alpha-2 subunit |
| Swissprots | Q14595 P17301 |
| Accessions | AAA16619 AAC94975 AAD14096 AAF77577 AAM34795 ADZ28531 ADZ28532 ADZ28533 AEO14637 AEO14638 CCF76999 EAW54872 EAW54873 P17301 AK307952 AU126174 BC143505 BC143508 BC143509 BC143511 BC143512 BC148596 AAI48597 BC156715 AAI56716 BE048389 BF355124 BG288116 BG494837 BG771368 BM828183 BM979113 BP280760 BP381403 CA442768 CK904145 CN272390 DA343078 DA545055 X17033 CAA34894 NM_002203 NP_002194 NR_073103 NR_073104 NR_073105 NR_073106 NR_073107 |
| Function | Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Top Pathways | Proteoglycans in cancer, Phagosome, PI3K-Akt signaling pathway, Focal adhesion, Dilated cardiomyopathy |