ITGA2

Gene Symbol ITGA2
Entrez Gene 3673
Alt Symbol BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2
Species Human
Gene Type protein-coding
Description integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Other Description CD49 antigen-like family member B|VLA2 receptor, alpha-2 subunit|collagen receptor|human platelet alloantigen system 5|integrin alpha-2|platelet antigen Br|platelet glycoprotein GPIa|platelet membrane glycoprotein Ia|very late activation protein 2 receptor, alpha-2 subunit
Swissprots Q14595 P17301
Accessions AAA16619 AAC94975 AAD14096 AAF77577 AAM34795 ADZ28531 ADZ28532 ADZ28533 AEO14637 AEO14638 CCF76999 EAW54872 EAW54873 P17301 AK307952 AU126174 BC143505 BC143508 BC143509 BC143511 BC143512 BC148596 AAI48597 BC156715 AAI56716 BE048389 BF355124 BG288116 BG494837 BG771368 BM828183 BM979113 BP280760 BP381403 CA442768 CK904145 CN272390 DA343078 DA545055 X17033 CAA34894 NM_002203 NP_002194 NR_073103 NR_073104 NR_073105 NR_073106 NR_073107
Function Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Subcellular Location Membrane; Single-pass type I membrane protein.
Top Pathways Proteoglycans in cancer, Phagosome, PI3K-Akt signaling pathway, Focal adhesion, Dilated cardiomyopathy

Integrin α2 (H-293) - sc-9089 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Integrin α2 (H-293): sc-9089. Western blot analysis of human recombinant Integrin α2 fusion protein.

Integrin α2 (N-19) - sc-6586 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Integrin α2 (N-19): sc-6586. Western blot analysis of Integrin α2 expression in BJAB (A), CCRF-CEM (B) and CCRF-HSB-2 (C) whole cell lysates.

Integrin α2 (C-9) - sc-74466 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α2 (C-9): sc-74466. Western blot analysis of Integrin α2 expression in BJAB (A) CCRF-HSB-2 (B) and human PBL (C) whole cell lysates.

Integrin α2 (P1H5) - sc-13546 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α2 (P1H5) PE: sc-13546 PE. FCM analysis of human peripheral blood leukocytes. Quadrant markers were set based on the isotype control, normal mouse IgG<sub>2b</sub>: sc-2868.

Integrin α2 (P1E6) - sc-53502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α2 (P1E6): sc-53502. Western blot analysis of Integrin α2 expression in human platelet extract (A) and human PBL whole cell lysate (B) under non-reducing conditions.

Integrin α2 (HAS-4) - sc-53353 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α2 (HAS-4): sc-53353. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin α2 (HAS-4), followed by PE-conjugated goat anti-mouse IgG<sub>2a</sub>: sc-3765. Black line histogram represents the isotype control, normal mouse IgG<sub>2a</sub>: sc-3878.

Integrin α2 (P4B4) - sc-53506 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α2 (P4B4): sc-53506. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

Integrin α2 (HAS-3) - sc-53352 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Integrin α2 (HAS-3): sc-53352. Indirect FCM analysis of human peripheral blood leukocytes stained with Integrin α2 (HAS-3), followed by PE-conjugated goat anti-mouse IgG<sub>2a</sub>: sc-3765. Black line histogram represents the isotype control, normal mouse IgG<sub>2a</sub>: sc-3878.

Integrin α2 (2) - sc-136257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Integrin α2 (2): sc-136257. Immunofluorescence staining of WiDr cells showing membrane localization.

Anti-CD49b antibody [TEA1/41] (CF405M) - ab115797 from Abcam

Prices $216.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone TEA1/41
ab115797 at 5µl/106 cells staining CD49b in Human platelets by Flow Cytometry (shown in red). Isotype control (blue).

Anti-Integrin alpha 2 antibody - ab55340 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Integrin alpha 2 antibody - ab94959 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Integrin alpha 2 antibody (ab94959) at 1/100 dilution + MDA-MB231 cell line lysates at 35 µg

Anti-Integrin alpha 2 antibody [AK7] (FITC) - ab30486 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone AK7
Flow cytometric analysis of human peripheral blood platlets with 10µl for 106 cells of anti human CD49b FITC conjugated (ab30486).

Anti-Integrin alpha 2 antibody [EPR17338] - C-terminal - ab181548 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR17338
Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling Integrin alpha 2 with ab181548 at 1/500 dilution followed by Goat Anti-Rabbit HRP (IgG H&L) (ab97051) at 1/500 dilution. Membrane and weak cytoplasmic staining on epithelial cells of human colon is observed. Counter stained with Hematoxylin.Negative control: Used PBS instead of primary antibody.

Anti-Integrin alpha 2 antibody [EPR5788] - ab133557 from Abcam

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5788
All lanes : Anti-Integrin alpha 2 antibody [EPR5788] (ab133557) at 1/10000 dilution (purified)Lane 1 : T47-D cell lysateLane 2 : HEK293 cell lysateLysates/proteins at 20 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-Integrin alpha 2 antibody [EPR5789] - ab109432 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5789
All lanes : Anti-Integrin alpha 2 antibody [EPR5789] (ab109432) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : T47-D cell lysate Lane 3 : A431 cell lysateLysates/proteins at 10 µg per lane.

Anti-Integrin alpha 2 antibody [HAS-3] - ab10800 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone HAS-3
Immunohistochemical analysis of Human blood vessels, staining Integrin alpha 2 with ab10800.Tissue was fixed with formaldehyde and blocked with 3% goat serum for 30 minutes at 21°C; antigen retrieval was by an enzymatic method. Samples were incubated with primary antibody (1/10 in diluent) for 1 hour at 21°C. An undiluted streptavidin-conjugated goat anti-mouse polyclonal IgG was used as the secondary antibody. See Abreview

Anti-Integrin alpha 2 antibody [HAS-4] - ab10801 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone HAS-4

Anti-Integrin alpha 2 antibody [HAS-4] (FITC) - ab87027 from Abcam

Prices $185.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone HAS-4

Anti-Integrin alpha 2 antibody [TEA1/41] - ab90985 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TEA1/41

Anti-Integrin alpha 2 antibody [TEA1/41] (FITC) - ab91014 from Abcam

Prices $376.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone TEA1/41
ab91014 at 20µl for 106 cells staining Integrin alpha 2 in Human platelets by Flow Cytometry.

Anti-Integrin alpha 2 antibody [TEA1/41] (Phycoerythrin) - ab91013 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone TEA1/41

Anti-Integrin alpha 2+beta 1 antibody [16B4] - ab30483 from Abcam

Prices $391.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 16B4
Overlay histogram showing HT1080 cells stained with ab30483 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab30483, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was a goat anti-mouse Alexa Fluor® 488 (IgG; H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HT1080 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Integrin alpha 2+beta 1 antibody [P1E6] - ab24697 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone P1E6
Overlay histogram showing HT1080 cells stained with ab24697 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab24697, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was a goat anti-mouse DyLight® 488 (IgG; H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive result in 80% methanol (5 min) fixed HT1080 cells used under the same conditions.Please note that Abcam do not have any data for use of this antibody on non-fixed cells. We welcome any customer feedback.

Anti-Integrin alpha 2+beta 1 antibody [P1E6] - ab78883 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone P1E6
ICC/IF image of ab78883 stained HepG2 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab78883, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM. This antibody also gave a positive result in 4% formaldehyde fixed (10 min) MCF7 cells at 5µg/ml.
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