| Gene Symbol |
KRT2
|
| Entrez Gene |
3849
|
| Alt Symbol |
CK-2e, K2e, KRT2A, KRT2E, KRTE
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin 2, type II
|
| Other Description |
cytokeratin-2e|epithelial keratin-2e|keratin, type II cytoskeletal 2 epidermal|keratin-2 epidermis|keratin-2e|type-II keratin Kb2
|
| Swissprots |
Q4VAQ2 P35908
|
| Accessions |
AAB81946 EAW96641 P35908 AL598277 BC096294 AAH96294 BC099643 AAH99643 BC099644 AAH99644 M99061 AAC83410 NM_000423 NP_000414
|
| Function |
Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. {ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}.
|
| Tissue Specificity |
Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization. {ECO:0000269|PubMed:10233306, ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}.
|
![Western Blot: Cytokeratin 2 Overexpression Lysate (Adult Normal) [NBP2-10668] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Cytokeratin 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10427_Cytokeratin%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10668-img0001.jpg)