Gene Symbol | KRT2 |
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Entrez Gene | 3849 |
Alt Symbol | CK-2e, K2e, KRT2A, KRT2E, KRTE |
Species | Human |
Gene Type | protein-coding |
Description | keratin 2, type II |
Other Description | cytokeratin-2e|epithelial keratin-2e|keratin, type II cytoskeletal 2 epidermal|keratin-2 epidermis|keratin-2e|type-II keratin Kb2 |
Swissprots | Q4VAQ2 P35908 |
Accessions | AAB81946 EAW96641 P35908 AL598277 BC096294 AAH96294 BC099643 AAH99643 BC099644 AAH99644 M99061 AAC83410 NM_000423 NP_000414 |
Function | Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. {ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}. |
Tissue Specificity | Expressed in the upper spinous and granular suprabasal layers of normal adult epidermal tissues from most body sites including thigh, breast nipple, foot sole, penile shaft and axilla. Not present in foreskin, squamous metaplasias and carcinomas. Expression in hypertrophic and keloid scars begins in the deepest suprabasal layer. Weakly expressed in normal gingiva and tongue, however expression is induced in benign keratoses of lingual mucosa and in mild-to-moderate oral dysplasia with orthokeratinization. {ECO:0000269|PubMed:10233306, ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}. |
Keratin 2 CRISPR/Cas9 KO Plasmid (h) - sc-402077 from Santa Cruz Biotechnology
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Keratin 2 HDR Plasmid (h) - sc-402077-HDR from Santa Cruz Biotechnology
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Keratin 2 Double Nickase Plasmid (h) - sc-402077-NIC from Santa Cruz Biotechnology
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Keratin 2 Double Nickase Plasmid (h2) - sc-402077-NIC-2 from Santa Cruz Biotechnology
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Keratin 2 CRISPR Activation Plasmid (h) - sc-402077-ACT from Santa Cruz Biotechnology
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Keratin 2 CRISPR Activation Plasmid (h2) - sc-402077-ACT-2 from Santa Cruz Biotechnology
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Keratin 2 Lentiviral Activation Particles (h) - sc-402077-LAC from Santa Cruz Biotechnology
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Keratin 2 Lentiviral Activation Particles (h2) - sc-402077-LAC-2 from Santa Cruz Biotechnology
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Keratin 2 siRNA (h) - sc-95659 from Santa Cruz Biotechnology
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Keratin 2 shRNA Plasmid (h) - sc-95659-SH from Santa Cruz Biotechnology
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Keratin 2 shRNA (h) Lentiviral Particles - sc-95659-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN11368 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11368 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04506 from Sigma-Aldrich
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KRT2 siRNA (Human) - CRH2610 from Cohesion Biosciences
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shRNA set against Human KRT2 (NM_000423.2) - SHH327327 from Creative biogene
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shRNA set against Human KRT2(NM_000423.2) - SHL205732 from Creative biogene
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Human KRT2 siRNA - orb263112 from Biorbyt
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KRT2 shRNA Plasmid (Human) - CHH2610 from Cohesion Biosciences
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KRT2 miRNA 3'UTR clone - MiUTR1H-05445 from Creative biogene
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