Gene Symbol | DAZ1 |
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Entrez Gene | 1617 |
Alt Symbol | DAZ, SPGY |
Species | Human |
Gene Type | protein-coding |
Description | deleted in azoospermia 1 |
Other Description | deleted in azoospermia protein 1 |
Swissprots | Q9NQZ4 Q1RMF9 Q9NQZ3 |
Accessions | AAL24501 AAR31726 AAR31727 AAR31728 AAR31729 AAS55959 AAS78586 Q9NQZ3 AF271087 AAF91405 AF271088 AAF91406 AK310133 BC114927 AAI14928 DB461291 U66077 XM_011531482 XP_011529784 XM_011531483 XP_011529785 NM_004081 NP_004072 |
Function | RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells. {ECO:0000269|PubMed:19865085}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11058556}. Nucleus {ECO:0000269|PubMed:11058556}. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis. |
Tissue Specificity | Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia (at protein level). {ECO:0000269|PubMed:10936047, ECO:0000269|PubMed:18385127, ECO:0000269|PubMed:19223287}. |
Human DAZ1 protein fragment - ab158262 from Abcam
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DAZ1 / DAZ Antibody Blocking Peptide - LS-E21484 from LifeSpan Bioscience
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Recombinant Human DAZ1 Protein - H00001617-Q01 from Novus Biologicals
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DAZ1 Blocking Peptide - 33R-6391 from Fitzgerald
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DAZ1 - H00001617-Q01-10 from Acris Antibodies
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DAZ1 - H00001617-Q01-25 from Acris Antibodies
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Recombinant Human Deleted in azoospermia protein 1(DAZ1) - CSB-YP868293HU CSB-EP868293HU CSB-BP868293HU CSB-MP868293HU from Cusabio
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DAZ1 Protein - abx164163 from Abbexa
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DAZ-Antibody-N-term-Blocking-Peptide - BP7739a from Abgent, a WuXi AppTec company
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DAZ1 Peptide, Human - M34GP04033H from Creative Peptides
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Deleted in azoospermia protein 1 (DAZ1), Recombinant Protein - MBS1446045 from MyBioSource
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Recombinant Human DAZ1 Protein, GST-tagged - DAZ1-2354H from Creative Biomart
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