Gene Symbol | PGAM2 |
---|---|
Entrez Gene | 5224 |
Alt Symbol | GSD10, PGAM-M, PGAMM |
Species | Human |
Gene Type | protein-coding |
Description | phosphoglycerate mutase 2 (muscle) |
Other Description | BPG-dependent PGAM 2|muscle-specific phosphoglycerate mutase|phosphoglycerate mutase 2|phosphoglycerate mutase isozyme M |
Swissprots | P15259 |
Accessions | AAA60073 AAA64238 CBX85731 CBX85913 EAL23769 EAW61128 P15259 BC001904 AAH01904 BC073741 AAH73741 CT002473 M18172 AAA60072 XM_011515426 XP_011513728 NM_000290 NP_000281 |
Function | Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. |
Tissue Specificity | In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues. |
Top Pathways | Glycolysis / Gluconeogenesis, Glycine, serine and threonine metabolism, Central carbon metabolism in cancer, Glucagon signaling pathway, Biosynthesis of amino acids |