| Gene Symbol |
RHOD
|
| Entrez Gene |
29984
|
| Alt Symbol |
ARHD, RHOHP1, RHOM, Rho
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ras homolog family member D
|
| Other Description |
Rho-related protein HP1|ras homolog D|ras homolog gene family, member A|ras homolog gene family, member D|rho-related GTP-binding protein RhoD
|
| Swissprots |
O00212
|
| Accessions |
BAA19652 CAI61861 EAW74577 O00212 AF498973 AAM21120 BC001338 AAH01338 BM761353 BM761362 CA433897 CB853597 CN305061 DQ891124 ABM82050 DQ894303 ABM85229 LN607835 CEF49522 NM_001300886 NP_001287815 NM_014578 NP_055393
|
| Function |
Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. {ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:24102721}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:24102721}. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250|UniProtKB:P97348}.
|
| Tissue Specificity |
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
|
| Top Pathways |
Axon guidance
|