Gene Symbol | RHOD |
---|---|
Entrez Gene | 29984 |
Alt Symbol | ARHD, RHOHP1, RHOM, Rho |
Species | Human |
Gene Type | protein-coding |
Description | ras homolog family member D |
Other Description | Rho-related protein HP1|ras homolog D|ras homolog gene family, member A|ras homolog gene family, member D|rho-related GTP-binding protein RhoD |
Swissprots | O00212 |
Accessions | BAA19652 CAI61861 EAW74577 O00212 AF498973 AAM21120 BC001338 AAH01338 BM761353 BM761362 CA433897 CB853597 CN305061 DQ891124 ABM82050 DQ894303 ABM85229 LN607835 CEF49522 NM_001300886 NP_001287815 NM_014578 NP_055393 |
Function | Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. {ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:24102721}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:24102721}. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250|UniProtKB:P97348}. |
Tissue Specificity | Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues. |
Top Pathways | Axon guidance |
Rho D CRISPR/Cas9 KO Plasmid (h) - sc-408686 from Santa Cruz Biotechnology
|
||||||||
Rho D HDR Plasmid (h) - sc-408686-HDR from Santa Cruz Biotechnology
|
||||||||
Rho D Double Nickase Plasmid (h) - sc-408686-NIC from Santa Cruz Biotechnology
|
||||||||
Rho D Double Nickase Plasmid (h2) - sc-408686-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Rho D CRISPR Activation Plasmid (h) - sc-408686-ACT from Santa Cruz Biotechnology
|
||||||||
Rho D CRISPR Activation Plasmid (h2) - sc-408686-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Rho D Lentiviral Activation Particles (h) - sc-408686-LAC from Santa Cruz Biotechnology
|
||||||||
Rho D Lentiviral Activation Particles (h2) - sc-408686-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Rho D siRNA (h) - sc-60032 from Santa Cruz Biotechnology
|
||||||||
Rho D shRNA Plasmid (h) - sc-60032-SH from Santa Cruz Biotechnology
|
||||||||
Rho D shRNA (h) Lentiviral Particles - sc-60032-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU039171 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN18255 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18255 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03065 from Sigma-Aldrich
|
||||||||
RHOD siRNA (Human) - CRH9314 from Cohesion Biosciences
|
||||||||
RhoD RNAi - H00029984-R01 from Novus Biologicals
|
||||||||
RHOD - MBS8210612 from MyBioSource
|
||||||||
RHOD shRNA Plasmid (Human) - CHH9314 from Cohesion Biosciences
|
||||||||
RHOD miRNA 3'UTR clone - MiUTR3H-07952 from Creative biogene
|