Gene Symbol | RHOD |
---|---|
Entrez Gene | 29984 |
Alt Symbol | ARHD, RHOHP1, RHOM, Rho |
Species | Human |
Gene Type | protein-coding |
Description | ras homolog family member D |
Other Description | Rho-related protein HP1|ras homolog D|ras homolog gene family, member A|ras homolog gene family, member D|rho-related GTP-binding protein RhoD |
Swissprots | O00212 |
Accessions | BAA19652 CAI61861 EAW74577 O00212 AF498973 AAM21120 BC001338 AAH01338 BM761353 BM761362 CA433897 CB853597 CN305061 DQ891124 ABM82050 DQ894303 ABM85229 LN607835 CEF49522 NM_001300886 NP_001287815 NM_014578 NP_055393 |
Function | Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. {ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:24102721}. |
Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:24102721}. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250|UniProtKB:P97348}. |
Tissue Specificity | Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues. |
Top Pathways | Axon guidance |
Rho D (H-1) - sc-376340 from Santa Cruz Biotechnology
|
||||||||||
Rho D (H-6) - sc-365241 from Santa Cruz Biotechnology
|
||||||||||
Rho D (H-50) - sc-50388 from Santa Cruz Biotechnology
|
||||||||||
Rho D (L-18) - sc-27880 from Santa Cruz Biotechnology
|
||||||||||
Rho D (N-18) - sc-27879 from Santa Cruz Biotechnology
|
||||||||||
Anti-RHOD antibody - ab80537 from Abcam
|
||||||||||
Anti-RHOD antibody - ab138081 from Abcam
|
||||||||||
Anti-RHOD antibody [2F7] - ab119301 from Abcam
|
||||||||||
Anti-RHOD antibody [EPR7027] - N-terminal - ab185211 from Abcam
|
||||||||||
Anti-RHOD Antibody (aa156-201) - LS-C313921 from LifeSpan Bioscience
|
||||||||||
Anti-RHOD Antibody (aa97-146) - LS-C200601 from LifeSpan Bioscience
|
||||||||||
Anti-RHOD Antibody (N-Terminus) - LS-C80500 from LifeSpan Bioscience
|
||||||||||
Anti-RHOD Antibody - LS-C334737 from LifeSpan Bioscience
|
||||||||||
Anti-RHOD Antibody (clone 2F7) - LS-C173500 from LifeSpan Bioscience
|
||||||||||
Anti-RHOD Antibody (C-Terminus) IHC-plus⢠- LS-B6828 from LifeSpan Bioscience
|
||||||||||
RhoD Antibody - NBP1-58359 from Novus Biologicals
|
||||||||||
RhoD Antibody - NBP1-88833 from Novus Biologicals
|
||||||||||
RhoD Antibody (2F7) - NBP2-01462 from Novus Biologicals
|
||||||||||
RhoD Antibody (1E7) - H00029984-M12 from Novus Biologicals
|
||||||||||
Anti-RHOD antibody produced in rabbit - HPA024394 from Sigma-Aldrich
|
||||||||||
Anti-RHOD (AB1) antibody produced in rabbit - AV42413 from Sigma-Aldrich
|
||||||||||
Monoclonal Anti-RHOD antibody produced in mouse - SAB1403218 from Sigma-Aldrich
|
||||||||||
RHOD antibody - N-terminal region (ARP42413_P050) - ARP42413_P050 from Aviva Systems Biology
|
||||||||||
RHOD antibody - C-terminal region (ARP42414_P050) - ARP42414_P050 from Aviva Systems Biology
|
||||||||||
RhoD-Antibody - AP51474 from Abgent, a WuXi AppTec company
|