| Gene Symbol |
MED25
|
| Entrez Gene |
81857
|
| Alt Symbol |
ACID1, ARC92, CMT2B2, P78, PTOV2, TCBAP0758
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 25
|
| Other Description |
ARC/mediator transcriptional coactivator subunit|activator interaction domain-containing protein 1|activator-recruited cofactor 92 kDa component|mediator of RNA polymerase II transcription subunit 25|mediator of RNA polymerase II transcription, subunit 25 homolog|prostate-derived protein 78 kDa
|
| Swissprots |
Q9HB34 Q707U4 O95783 Q71SY5 Q8TB55 B9TX30 Q6P143 Q9H0L5 Q6QMH5 A8K095
|
| Accessions |
AAD15565 EAW52544 EAW52545 EAW52546 EAW52547 EAW52548 EAW52549 EAW52550 EAW52551 Q71SY5 AF261072 AAM20739 AF283769 AAG15589 AF447873 AAQ04648 AJ617479 CAE84581 AK055844 BAG51583 AK289460 BAF82149 AK298897 BAG61008 AK307330 AL136746 CAB66680 AY533507 AAS45401 BC021543 BC024312 AAH24312 BC065297 AAH65297 BG770032 BI520216 DC410997 EU392499 ACB88861 EU392500 ACB88862 EU392501 ACB88863 EU392502 ACB88864 EU392503 ACB88865 EU392504 ACB88866 EU392505 ACB88867 EU392506 ACB88868 EU392507 ACB88869 EU392508 ACB88870 EU392509 ACB88871 EU392510 ACB88872 EU392511 ACB88873 EU392512 ACB88874 EU392513 ACB88875 EU392514 ACB88876 EU392515 ACB88877 EU392516 ACB88878 EU392517 ACB88879 EU392518 ACB88880 EU392519 EU832505 ACE87677 EU832586 ACE86988 XM_011527353 XP_011525655 NM_030973 NP_112235
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011, ECO:0000269|PubMed:17641689}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14657022}.
|
| Tissue Specificity |
Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen. {ECO:0000269|PubMed:14657022, ECO:0000269|PubMed:14983011}.
|