DDX20

Gene Symbol	DDX20
Entrez Gene	11218
Alt Symbol	DP103, GEMIN3
Species	Human
Gene Type	protein-coding
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Other Description	DEAD box protein 20|DEAD box protein DP 103|DEAD-box protein DP103|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD|SMN-interacting protein|component of gems 3|gemin-3|probable ATP-dependent RNA helicase DDX20
Swissprots	Q9UIY0 Q9NVM3 Q9Y659 Q9UHI6 Q9UF59 Q96F72 B4DWV7
Accessions	EAW56507 EAW56508 Q9UHI6 AF106019 AAD42744 AF155803 AAK56799 AF171063 AAF14544 AK001506 BAA91727 AK301697 BAG63169 AK314312 AL133598 CAB63734 AY007146 AAG02003 BC011556 AAH11556 BC031062 AAH31062 BC034953 AAH34953 DB072947 DQ892249 ABM83175 DQ895449 ABM86375 NM_007204 NP_009135
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.
Subcellular Location	Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
Tissue Specificity	Ubiquitous.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Gemin 3 full length protein - ab132034 from Abcam Category Protein Source Wheat germ Species Human

Human Gemin 3 full length protein - ab132035 from Abcam Category Protein Source Wheat germ Species Human

Human Gemin 3 protein fragment - ab126009 from Abcam Category Protein Source E. coli Species Human

DDX20 / GEMIN3 Antibody Blocking Peptide - LS-E3672 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DDX20 / GEMIN3 Antibody Blocking Peptide - LS-E13033 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Gemin 3 Recombinant Protein - H00011218-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Gemin 3 Protein - H00011218-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Gemin 3 Protein - H00011218-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DDX20-Antibody-C-term-Blocking-Peptide - BP14870b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DDX20 - H00011218-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DDX20 - H00011218-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DDX20 - H00011218-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

DDX20 - H00011218-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DDX20 - H00011218-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DDX20 - H00011218-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DDX20 - H00011218-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DDX20 fusion protein - ag1863 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Probable ATP-dependent RNA helicase DDX20(DDX20) ,partial - CSB-YP890695HU CSB-EP890695HU CSB-BP890695HU CSB-MP890695HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DDX20 - TP305247 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Probable ATP-dependent RNA helicase DDX20 (DDX20), partial, Recombinant Protein - MBS1410983 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Gemin 3 Recombinant Protein Antigen - NBP1-84059PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Gemin 3 Recombinant Protein Antigen - NBP1-84058PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DDX20 Peptide, Human - M34GP04141H from Creative Peptides Category Peptide Source Synthetic. Species Human

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