| Gene Symbol | NGFR |
|---|---|
| Entrez Gene | 4804 |
| Alt Symbol | CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR |
| Species | Human |
| Gene Type | protein-coding |
| Description | nerve growth factor receptor |
| Other Description | NGF receptor|TNFR superfamily, member 16|low affinity nerve growth factor receptor|low affinity neurotrophin receptor p75NTR|low-affinity nerve growth factor receptor|p75 ICD|tumor necrosis factor receptor superfamily member 16 |
| Swissprots | B2R961 P08138 B4E096 |
| Accessions | AAA36363 CAM36380 CBX53856 EAW94677 P08138 AK303278 BAG64358 AK313654 BAG36408 BC050309 AAH50309 BC052797 BQ639556 CK299927 DA115173 M14764 AAB59544 NM_002507 NP_002498 |
| Function | Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. {ECO:0000250, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:23785138}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Top Pathways | Cytokine-cytokine receptor interaction, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Rap1 signaling pathway, Transcriptional misregulation in cancer |