| Gene Symbol | SEPT8 |
|---|---|
| Entrez Gene | 23176 |
| Alt Symbol | SEP2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | septin 8 |
| Other Description | septin-8 |
| Swissprots | A6NKP6 A6NC65 Q92599 Q8IX36 Q9BVB3 F6W7K9 Q8IX37 |
| Accessions | EAW62315 EAW62316 EAW62317 Q92599 AF179995 AAG09407 AF440761 AAO13878 AF440762 AAO13879 AF440763 AAO13880 AI087126 AK057797 BC001329 AAH01329 BC140759 AAI40760 BC160179 AAI60179 BC171779 AAI71779 BU739074 D86957 BAA13193 DA261871 XM_005271927 XP_005271984 XM_005271928 XP_005271985 XM_005271931 XP_005271988 XM_011543288 XP_011541590 XM_011543289 XP_011541591 NM_001300798 NP_001287727 NM_001300799 NP_001287728 NM_001098811 NP_001092281 NM_001098812 NP_001092282 NM_001098813 NP_001092283 NM_015146 NP_055961 |
| Function | Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. {ECO:0000250, ECO:0000269|PubMed:15116257, ECO:0000305}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In platelets, found in areas surrounding alpha-granules. {ECO:0000269|PubMed:15116257}. |
| Tissue Specificity | Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary. {ECO:0000269|PubMed:12023038, ECO:0000269|PubMed:12909369, ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:15915442}. |
| Top Pathways | Bacterial invasion of epithelial cells |
Septin 8 CRISPR/Cas9 KO Plasmid (h) - sc-409836 from Santa Cruz Biotechnology
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Septin 8 HDR Plasmid (h) - sc-409836-HDR from Santa Cruz Biotechnology
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Septin 8 Double Nickase Plasmid (h) - sc-409836-NIC from Santa Cruz Biotechnology
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Septin 8 Double Nickase Plasmid (h2) - sc-409836-NIC-2 from Santa Cruz Biotechnology
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Septin 8 CRISPR Activation Plasmid (h) - sc-409836-ACT from Santa Cruz Biotechnology
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Septin 8 CRISPR Activation Plasmid (h2) - sc-409836-ACT-2 from Santa Cruz Biotechnology
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Septin 8 Lentiviral Activation Particles (h) - sc-409836-LAC from Santa Cruz Biotechnology
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Septin 8 Lentiviral Activation Particles (h2) - sc-409836-LAC-2 from Santa Cruz Biotechnology
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Septin 8 siRNA (h) - sc-61530 from Santa Cruz Biotechnology
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Septin 8 shRNA Plasmid (h) - sc-61530-SH from Santa Cruz Biotechnology
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Septin 8 shRNA (h) Lentiviral Particles - sc-61530-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU088851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19111 from Sigma-Aldrich
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SEPT8 siRNA (Human) - CRH8059 from Cohesion Biosciences
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SEPT8 - MBS8212943 from MyBioSource
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shRNA set against Human SEPT8 (NM_001098811.1) - SHH404672 from Creative biogene
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shRNA set against Human SEPT8(NM_001098812.1) - SHR215772 from Creative biogene
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SEPT8 shRNA Plasmid (Human) - CHH8059 from Cohesion Biosciences
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SEPT8 miRNA 3'UTR clone - MiUTR1H-09279 from Creative biogene
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SEPT8 miRNA 3'UTR clone - MiUTR3H-09984 from Creative biogene
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