Gene Symbol | SLC12A7 |
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Entrez Gene | 10723 |
Alt Symbol | KCC4 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 12 (potassium/chloride transporter), member 7 |
Other Description | K-Cl cotransporter 4|electroneutral potassium-chloride cotransporter 4|potassium/chloride transporter KCC4|solute carrier family 12 (potassium/chloride transporters), member 7|solute carrier family 12 member 7 |
Swissprots | A6NDS8 Q9H7I3 Q9Y666 Q4G0F3 Q9H7I7 Q9UFW2 Q96I81 |
Accessions | CAH25944 EAX08178 EAX08179 EAX08180 EAX08181 Q9Y666 AF105365 AAD39741 AK024493 BAB15783 AK024497 BAB15787 AK026625 AK302856 BAG64042 AL117433 CAB55921 BC007760 AAH07760 BC018982 BC098390 AAH98390 BU953746 DB451347 XM_005248231 XP_005248288 XM_006725006 XP_006725069 XM_011513939 XP_011512241 XM_011513940 XP_011512242 XM_011513941 XP_011512243 XM_011546472 XP_011544774 XM_011546473 XP_011544775 XM_011546474 XP_011544776 XR_925579 XR_925580 XR_925582 XR_951676 XR_951677 XR_951678 NM_006598 NP_006589 |
Function | Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Detected in muscle, brain, lung, heart and kidney. |
Top Pathways | Collecting duct acid secretion |
KCC4 (C-12) - sc-19427 from Santa Cruz Biotechnology
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KCC4 (H-44) - sc-368187 from Santa Cruz Biotechnology
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KCC4 (L-13) - sc-19426 from Santa Cruz Biotechnology
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Anti-KCC4 antibody - ab78912 from Abcam
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Anti-KCC4 antibody - ab168941 from Abcam
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Anti-KCC4 antibody - ab96424 from Abcam
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Anti-KCC4 antibody - N-terminal - ab170623 from Abcam
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Anti-SLC12A7 / KCC4 Antibody (N-Terminus) - LS-C16129 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (N-Terminal) - LS-C16130 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (C-Terminus) - LS-C37120 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa951-962) - LS-C55026 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (Internal) - LS-C145145 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa96-125, AP) - LS-C224082 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa96-125, APC) - LS-C224083 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa96-125, Biotin) - LS-C224084 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa96-125, FITC) - LS-C224085 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa96-125, Azide-free, HRP) - LS-C224086 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa96-125, PE) - LS-C224087 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa96-125) - LS-C330142 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa950-1000) - LS-C291078 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa1-50) - LS-C291079 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa845-1083) - LS-C185497 from LifeSpan Bioscience
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Anti-SLC12A7 / KCC4 Antibody (aa89-117) - LS-C161130 from LifeSpan Bioscience
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KCC4/SLC12A7 Antibody - NBP1-85133 from Novus Biologicals
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KCC4/SLC12A7 Antibody - H00010723-B01 from Novus Biologicals
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