| Gene Symbol |
SLC12A7
|
| Entrez Gene |
10723
|
| Alt Symbol |
KCC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 12 (potassium/chloride transporter), member 7
|
| Other Description |
K-Cl cotransporter 4|electroneutral potassium-chloride cotransporter 4|potassium/chloride transporter KCC4|solute carrier family 12 (potassium/chloride transporters), member 7|solute carrier family 12 member 7
|
| Swissprots |
A6NDS8 Q9H7I3 Q9Y666 Q4G0F3 Q9H7I7 Q9UFW2 Q96I81
|
| Accessions |
CAH25944 EAX08178 EAX08179 EAX08180 EAX08181 Q9Y666 AF105365 AAD39741 AK024493 BAB15783 AK024497 BAB15787 AK026625 AK302856 BAG64042 AL117433 CAB55921 BC007760 AAH07760 BC018982 BC098390 AAH98390 BU953746 DB451347 XM_005248231 XP_005248288 XM_006725006 XP_006725069 XM_011513939 XP_011512241 XM_011513940 XP_011512242 XM_011513941 XP_011512243 XM_011546472 XP_011544774 XM_011546473 XP_011544775 XM_011546474 XP_011544776 XR_925579 XR_925580 XR_925582 XR_951676 XR_951677 XR_951678 NM_006598 NP_006589
|
| Function |
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Detected in muscle, brain, lung, heart and kidney.
|
| Top Pathways |
Collecting duct acid secretion
|
![Western Blot: KCC4 Overexpression Lysate (Adult Normal) [NBP2-10402] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCC4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4470_KCC4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10402-img0001.jpg)