| Gene Symbol |
RAB10
|
| Entrez Gene |
10890
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB10, member RAS oncogene family
|
| Other Description |
GTP-binding protein RAB10|ras-related GTP-binding protein|ras-related protein Rab-10
|
| Swissprots |
Q6IA52 P61026 Q9H0T3 D6W538
|
| Accessions |
AAX93140 AAY24262 EAX00710 EAX00711 P61026 AF086917 AAP97147 AF091032 AAF00045 AF106681 AAD43034 AF297660 AAG13413 AF498945 AAM21093 AK023223 BAB14474 AK025136 AL136650 CAB66585 AL517754 BC000896 AAH00896 CR457303 CAG33584 DA295568 EU831649 ACE87249 EU831733 ACE86567 HQ447911 ADQ32395 NM_016131 NP_057215
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane. Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane. In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response. Plays also a specific role in asymmetric protein transport to the plasma membrane within the polarized neuron and epithelial cells. In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward
|
| Subcellular Location |
Cytoplasmic vesicle membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Endosome membrane. Recycling endosome membrane. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Cell projection, cilium. Endoplasmic reticulum membrane. Note=Associates with SLC2A4/GLUT4 storage vesicles. Localizes to the base of the cilium. Transiently associates with phagosomes (By similarity). According to PubMed:23263280 localizes to the endoplasmic reticulum at domains of new tubule growth. {ECO:0000250}.
|
| Top Pathways |
AMPK signaling pathway
|
![Western Blot: RAB10 Overexpression Lysate (Adult Normal) [NBL1-15037] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAB10.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7354_RAB10%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15037-img0002.jpg)