IL17C

Gene Symbol	IL17C
Entrez Gene	27189
Alt Symbol	CX2, IL-17C
Species	Human
Gene Type	protein-coding
Description	interleukin 17C
Other Description	cytokine CX2\|interleukin-17C
Swissprots	Q3MIG8 Q9P0M4 Q9HC75
Accessions	CAH18037 CAL40892 CAO02250 CAS97406 CAT03419 EAW66798 Q9P0M4 AF152099 AAF28105 AY358471 AAQ88835 BC069152 AAH69152 BC069410 BC101835 AAI01836 BC112196 AAI12197 NM_013278 NP_037410
Function	Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. {ECO:0000269\|PubMed:21993848}.
Subcellular Location	Secreted.

Category	Cell Line
Species	Human

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