GCNT3

Gene Symbol GCNT3
Entrez Gene 9245
Alt Symbol C2/4GnT, C24GNT, C2GNT2, C2GNTM, GNTM
Species Human
Gene Type protein-coding
Description glucosaminyl (N-acetyl) transferase 3, mucin type
Other Description C2GnT-mucin type|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3|beta1,6-N-acetylglucosaminyltransferase-M|beta1,6GlcNAc-transferase|core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase|hC2GnT-M|mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase
Swissprots O95395
Accessions CAC17334 CAC34676 EAW77571 EAW77572 O95395 AF038650 AAD21525 AF102542 AAD10824 AK312852 BAG35705 BC017032 AAH17032 BP243086 EF152283 ABM21534 HQ448271 ADQ32751 NM_004751 NP_004742
Function Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269|PubMed:9915862}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. {ECO:0000269|PubMed:17303715, ECO:0000269|PubMed:9915862}.
Top Pathways Mucin type O-Glycan biosynthesis

GCNT3 (D-7) - sc-398646 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GCNT3 (D-7): sc-398646. Western blot analysis of GCNT3 expression in HCT-116 whole cell lysate.

GCNT3 (E-14) - sc-160365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GCNT3 (H-67) - sc-382251 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GCNT3 (K-14) - sc-160367 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GCNT3 (L-21) - sc-133611 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
GCNT3 (L-21): sc-133611. Western blot analysis of GCNT3 expression in non-transfected: sc-110760 (A) and human GCNT3 transfected: sc-112929 (B) 293 whole cell lysates.

Anti-GCNT3 antibody - ab111371 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111371 at 1/100 dilution staining GCNT3 in A549 cells by Immunofluorescence. The image on the right is treated with the synthesized peptide.

Anti-GCNT3 antibody - ab98134 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Formalin-Fixed, Paraffin-Embedded Human colon tissue labelled with ab98134 at 2.5 µg/ml.

Anti-GCNT3 antibody - ab77726 from Abcam

Prices $359.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
Anti-GCNT3 antibody (ab77726) at 0.3 µg/ml + human lymph node lysate (in RIPA buffer) at 35 µg

Anti-GCNT3 antibody - ab150501 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon tissue labelling GCNT3 with ab150501 at 10 µg/ml.

Anti-GCNT3 antibody - ab92991 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 antibody - ab92992 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa390-418, AP) - LS-C257632 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa390-418, APC) - LS-C257633 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa390-418, FITC) - LS-C257634 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa390-418, Biotin) - LS-C257635 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa390-418, Azide-free, HRP) - LS-C257636 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa390-418, PE) - LS-C257637 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa73-102, AP) - LS-C257638 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa410-422) - LS-C61744 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Duodenum lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-GCNT3 Antibody (aa73-102, APC) - LS-C257640 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa73-102, Biotin) - LS-C257642 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa273-284) - LS-C61743 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.3 ug/ml) staining of human lymph node lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-GCNT3 Antibody (C-Terminus) - LS-C80580 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
GCNT3 antibody LS-C80580 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-GCNT3 Antibody (aa73-102, FITC) - LS-C259485 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GCNT3 Antibody (aa73-102, Azide-free, HRP) - LS-C259486 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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