Gene Symbol | GCNT3 |
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Entrez Gene | 9245 |
Alt Symbol | C2/4GnT, C24GNT, C2GNT2, C2GNTM, GNTM |
Species | Human |
Gene Type | protein-coding |
Description | glucosaminyl (N-acetyl) transferase 3, mucin type |
Other Description | C2GnT-mucin type|beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3|beta1,6-N-acetylglucosaminyltransferase-M|beta1,6GlcNAc-transferase|core 2/core 4 beta-1,6-N-acetylglucosaminyltransferase|hC2GnT-M|mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase |
Swissprots | O95395 |
Accessions | CAC17334 CAC34676 EAW77571 EAW77572 O95395 AF038650 AAD21525 AF102542 AAD10824 AK312852 BAG35705 BC017032 AAH17032 BP243086 EF152283 ABM21534 HQ448271 ADQ32751 NM_004751 NP_004742 |
Function | Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269|PubMed:9915862}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced. {ECO:0000269|PubMed:17303715, ECO:0000269|PubMed:9915862}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
GCNT3 (D-7) - sc-398646 from Santa Cruz Biotechnology
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GCNT3 (E-14) - sc-160365 from Santa Cruz Biotechnology
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GCNT3 (H-67) - sc-382251 from Santa Cruz Biotechnology
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GCNT3 (K-14) - sc-160367 from Santa Cruz Biotechnology
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GCNT3 (L-21) - sc-133611 from Santa Cruz Biotechnology
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Anti-GCNT3 antibody - ab111371 from Abcam
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Anti-GCNT3 antibody - ab98134 from Abcam
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Anti-GCNT3 antibody - ab77726 from Abcam
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Anti-GCNT3 antibody - ab150501 from Abcam
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Anti-GCNT3 antibody - ab92991 from Abcam
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Anti-GCNT3 antibody - ab92992 from Abcam
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Anti-GCNT3 Antibody (aa390-418, AP) - LS-C257632 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa390-418, APC) - LS-C257633 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa390-418, FITC) - LS-C257634 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa390-418, Biotin) - LS-C257635 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa390-418, Azide-free, HRP) - LS-C257636 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa390-418, PE) - LS-C257637 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa73-102, AP) - LS-C257638 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa410-422) - LS-C61744 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa73-102, APC) - LS-C257640 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa73-102, Biotin) - LS-C257642 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa273-284) - LS-C61743 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (C-Terminus) - LS-C80580 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa73-102, FITC) - LS-C259485 from LifeSpan Bioscience
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Anti-GCNT3 Antibody (aa73-102, Azide-free, HRP) - LS-C259486 from LifeSpan Bioscience
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